Product Name
MRE11A, cDNA Clone
Full Product Name
MRE11A cDNA Clone
Product Gene Name
MRE11A cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgagtactg cagatgcact tgatgatgaa aacacattta aaatattagt tgcaacagat attcatcttg gatttatgga gaaagatgca gtcagaggaa atgatacgtt tgtaacactc gatgaaattt taagacttgc ccaggaaaat gaagtggatt ttattttgtt aggtggtgat ctttttcatg aaaataagcc ctcaaggaaa acattacata cctgcctcga gttattaaga aaatattgta tgggtgatcg gcctgtccag tttgaaattc tcagtgatca gtcagtcaac tttggtttta gtaagtttcc atgggtgaac tatcaagatg gcaacctcaa catttcaatt ccagtgttta gtattcatgg caatcatgac gatcccacag gggcagatgc actttgtgcc ttggacattt taagttgtgc tggatttgta aatcactttg gacgttcaat gtctgtggag aagatagaca ttagtccggt tttgcttcaa aaaggaagca caaagattgc gctatatggt ttaggatcca ttccagatga aaggctctat cgaatgtttg tcaataaaaa agtaacaatg ttgagaccaa aggaagatta g
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MRE11A cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MRE11A. It may not necessarily be applicable to this product.
NCBI Accession #
BC005241
[Other Products]
UniProt Secondary Accession #
O43475; B3KTC7[Other Products]
UniProt Related Accession #
P49959[Other Products]
Molecular Weight
81,070 Da
NCBI Official Full Name
Homo sapiens MRE11 meiotic recombination 11 homolog A (S. cerevisiae), mRNA
NCBI Official Synonym Full Names
MRE11 homolog A, double strand break repair nuclease
NCBI Official Symbol
MRE11A??[Similar Products]
NCBI Official Synonym Symbols
ATLD; HNGS1; MRE11; MRE11B
??[Similar Products]
NCBI Protein Information
double-strand break repair protein MRE11A
UniProt Protein Name
Double-strand break repair protein MRE11A
UniProt Synonym Protein Names
Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A
Protein Family
Double-strand break repair protein
UniProt Gene Name
MRE11A??[Similar Products]
UniProt Synonym Gene Names
HNGS1; MRE11; MRE11 homolog 1; MRE11 homolog A??[Similar Products]
UniProt Entry Name
MRE11_HUMAN
NCBI Summary for MRE11A
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for MRE11A
MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.
Protein type: Deoxyribonuclease; Cell cycle regulation; DNA-binding; DNA repair, damage
Chromosomal Location of Human Ortholog: 11q21
Cellular Component: cell-cell adherens junction; chromosome, telomeric region; cytoplasm; cytosol; Mre11 complex; nuclear chromosome, telomeric region; nucleoplasm; nucleus; PML body
Molecular Function: 3'-5' exonuclease activity; ATP-dependent DNA helicase activity; DNA binding; double-stranded DNA binding; endodeoxyribonuclease activity; nuclease activity; protein binding; protein C-terminus binding; single-stranded DNA specific endodeoxyribonuclease activity
Biological Process: DNA double-strand break processing; DNA duplex unwinding; DNA recombination; DNA repair; DNA replication; DNA synthesis during DNA repair; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; intra-S DNA damage checkpoint; meiotic recombination; negative regulation of apoptosis; negative regulation of DNA endoreduplication; positive regulation of interferon type I production; positive regulation of kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of telomere maintenance; regulation of mitotic recombination; response to DNA damage stimulus; sister chromatid cohesion; strand displacement; telomere maintenance via telomerase; telomeric 3' overhang formation
Disease: Ataxia-telangiectasia-like Disorder 1
Research Articles on MRE11A
1. a significant increase in DKC1, RAD50, MRE11 and RPA1 expression in MM cases with high bone marrow infiltration (p
Precautions
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Disclaimer
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