Mouse Inversin (INVS) ELISA kit; RP11-208F1.1; INV; KIAA0573; MGC133080; MGC133081; NPH2; NPHP2; inversion of embryonic turning; nephrocystin 2; inversin

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of INVS elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9334185 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the inversin (INVS) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing INVS. The ELISA analytical biochemical technique of the MBS9334185 kit is based on INVS antibody-INVS antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect INVS antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, INVS. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

117,129 Da

inversin

inversin; nephrocystin 2; inversion of embryo turning protein

Inversin

Inv; Nphp2??[Similar Products]

INVS_MOUSE

INVS: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis. Defects in INVS are the cause of nephronophthisis type 2 (NPHP2); also known as infantile nephronophthisis. NPHP2 is an autosomal recessive disorder resulting in end-stage renal disease. It is characterized by early onset and rapid progression. Phenotypic manifestations include enlarged kidneys, chronic tubulo-interstitial nephritis, anemia, hyperkalemic metabolic acidosis. Some patients also display situs inversus. Pathologically, it differs from later-onset nephronophthisis by the absence of medullary cysts and thickened tubular basement membranes and by the presence of cortical microcysts. 3 isoforms of the human protein are produced by alternative splicing.

Cellular Component: microtubule; cytoskeleton; membrane; cytoplasm; nucleus

Molecular Function: calmodulin binding; protein binding

Biological Process: Wnt receptor signaling pathway; multicellular organismal development; pancreas development; organ development; kidney development; post-embryonic development

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