Product Name
PRKAG3, cDNA Clone
Full Product Name
PRKAG3 cDNA Clone
Product Gene Name
PRKAG3 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGGAGCCCG GGCTGGAGCA CGCACTGCGC AGGACCCCTT CCTGGAGCAG CCTTGGGGGT TCTGAGCATC AAGAGATGAG CTTCCTAGAG CAAGAAAACA GCAGCTCATG GCCATCACCA GCTGTGACCA GCAGCTCAGA AAGAATCCGT GGGAAACGGA GGGCCAAAGC CTTGAGATGG ACAAGGCAGA AGTCGGTGGA GGAAGGGGAG CCACCAGGTC AGGGGGAAGG TCCCCGGTCC AGGCCAGCTG CTGAGTCCAC CGGGCTGGAG GCCACATTCC CCAAGACCAC ACCCTTGGCT CAAGCTGATC CTGCCGGGGT GGGCACTCCA CCAACAGGGT GGGACTGCCT CCCCTCTGAC TGTACAGCCT CAGCTGCAGG CTCCAGCACA GATGATGTGG AGCTGGCCAC GGAGTTCCCA GCCACAGAGG CCTGGGAGTG TGAGCTAGAA GGCCTGCTGG AAGAGAGGCC TGCCCTGTGC CTGTCCCCGC AGGCCCCATT TCCCAAGCTG GGCTGGGATG ACGAACTGCG GAAACCCGGC GCCCAGATCT ACATGCGCTT CATGCAGGAG CACACCTGCT ACGATGCCAT GGCAACTAGC TCCAAGCTAG TCATCTTCGA CACCATGCTG GAGATCAAGA AGGCCTTCTT TGCTCTGGTG GCCAACGGTG TGCGGGCAGC CCCTCTATGG GACAGCAAGA AGCAGAGCTT TGTGGGGATG CTGACCATCA CTGACTTCAT CCTGGTGCTG CATCGCTACT ACAGGTCCCC CCTGGTCCAG ATCTATGAGA TTGAACAACA TAAGATTGAG ACCTGGAGGG AGATCTACCT GCAAGGCTGC TTCAAGCCTC TGGTCTCCAT CTCTCCTAAT GATAGCCTGT TTGAAGCTGT CTACACCCTC ATCAAGAACC GGATCCATCG CCTGCCTGTT CTTGACCCGG TGTCAGGCAA CGTACTCCAC ATCCTCACAC ACAAACGCCT GCTCAAGTTC CTGCACATCT TTGGTTCCCT GCTGCCCCGG CCCTCCTTCC TCTACCGCAC TATCCAAGAT TTGGGCATCG GCACATTCCG AGACTTGGCT GTGGTGCTGG AGACAGCACC CATCCTGACT GCACTGGACA TCTTTGTGGA CCGGCGTGTG TCTGCACTGC CTGTGGTCAA CGAATGTGGT CAGGTCGTGG GCCTCTATTC CCGCTTTGAT GTGATTCACC TGGCTGCCCA GCAAACCTAC AACCACCTGG ACATGAGTGT GGGAGAAGCC CTGAGGCAGA GGACACTATG TCTGGAGGGA GTCCTTTCCT GCCAGCCCCA CGAGAGCTTG GGGGAAGTGA TCGACAGGAT TGCTCGGGAG CAGGTACACA GGCTGGTGCT AGTGGACGAG ACCCAGCATC TCTTGGGCGT GGTCTCCCTC TCCGACATCC TTCAGGCACT GGTGCTCAGC CCTGCTGGCA TCGATGCCCT CGGGGCCTGA
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of PRKAG3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PRKAG3. It may not necessarily be applicable to this product.
NCBI Accession #
BC098277
[Other Products]
UniProt Secondary Accession #
Q4QQG8; Q4V779; Q9NRL1[Other Products]
UniProt Related Accession #
Q9UGI9[Other Products]
Molecular Weight
51,484 Da
NCBI Official Full Name
Homo sapiens protein kinase, AMP-activated, gamma 3 non-catalytic subunit, mRNA
NCBI Official Synonym Full Names
protein kinase AMP-activated non-catalytic subunit gamma 3
NCBI Official Symbol
PRKAG3??[Similar Products]
NCBI Official Synonym Symbols
AMPKG3
??[Similar Products]
NCBI Protein Information
5'-AMP-activated protein kinase subunit gamma-3
UniProt Protein Name
5'-AMP-activated protein kinase subunit gamma-3
Protein Family
5'-AMP-activated protein kinase
UniProt Gene Name
PRKAG3??[Similar Products]
UniProt Synonym Gene Names
AMPKG3; AMPK gamma3; AMPK subunit gamma-3??[Similar Products]
UniProt Entry Name
AAKG3_HUMAN
NCBI Summary for PRKAG3
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq, Jul 2008]
UniProt Comments for PRKAG3
AMPKG3: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non- catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2. Skeletal muscle, with weak expression in heart and pancreas. Belongs to the 5'-AMP-activated protein kinase gamma subunit family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: cytosol; extracellular space; nucleoplasm
Molecular Function: protein kinase binding
Biological Process: cell cycle arrest; macroautophagy
Research Articles on PRKAG3
1. Low PRKAA2 expression is associated with follicular lymphoma.
Precautions
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Disclaimer
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