Product Name
BMP-13 (GDF6), Recombinant Protein
Full Product Name
Human BMP-13 (GDF6)
Product Synonym Names
Recombinant Human BMP-13
Product Gene Name
BMP-13 (GDF6) recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAY HCEG VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL T PISILYIDA GNNVVYKQYE DMVVESCGCR
Chromosome Location
Chromosome: 4; NC_000070.6 (9844372..9862345). Location: 4 A1; 4
3D Structure
ModBase 3D Structure for P43028
Purity/Purification
> 95% by SDS-PAGE
Endotoxin Level
< 0.1 ng per ug of BMP-13
Biological Activity
The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0 ug/ml.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of BMP-13 (GDF6) recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
BMP-13 (GDF6) recombinant protein
BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains. This 27.5 kDa protein is obtained by proteolytic processing of a
biologically inactive precursor protein of 97.7 kDa. Recombinant human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.
Product Categories/Family for BMP-13 (GDF6) recombinant protein
Cytokines & Growth Factors
NCBI/Uniprot data below describe general gene information for BMP-13 (GDF6). It may not necessarily be applicable to this product.
NCBI Accession #
NP_038554.1
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NCBI GenBank Nucleotide #
NM_013526.1
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UniProt Primary Accession #
P43028
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UniProt Secondary Accession #
Q70UT4[Other Products]
UniProt Related Accession #
P43028[Other Products]
NCBI Official Full Name
growth/differentiation factor 6
NCBI Official Synonym Full Names
growth differentiation factor 6
NCBI Official Symbol
Gdf6??[Similar Products]
NCBI Official Synonym Symbols
BMP13; GDF16
??[Similar Products]
NCBI Protein Information
growth/differentiation factor 6; GDF-6; growth differentiation factor 16; growth/differentiation factor 16
UniProt Protein Name
Growth/differentiation factor 6
UniProt Synonym Protein Names
Growth/differentiation factor 16
UniProt Gene Name
Gdf6??[Similar Products]
UniProt Synonym Gene Names
Gdf-6; Gdf16; GDF-6??[Similar Products]
UniProt Entry Name
GDF6_MOUSE
UniProt Comments for BMP-13 (GDF6)
Function: Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. May signal through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A. Ref.3 Ref.4 Ref.5
Subunit structure: Homodimer; disulfide-linked
By similarity.
Subcellular location: Secreted
By similarity.
Tissue specificity: Expressed in different subsets of developing joints. Ref.3
Disruption phenotype: Mice lacking Gdf6 display photoreceptor degeneration. Animals exhibit abnormal electroretinograms with up to 66% decreases in the bipolar cell-driven b-wave and 54% decreases in the photoreceptor-mediated a-wave amplitudes, as well as 3 to 27% reduced photopic flicker fusion. Ref.5
Sequence similarities: Belongs to the TGF-beta family.
Research Articles on BMP-13 (GDF6)
1. Over-expression of Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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