Gdf5; bp; brp; Cdmp-1

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 4; NC_000070.6 (9844372..9862345). Location: 4 A1; 4

E Coli

Lyophilized

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of GDF-5/CDMP-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities, and in Hunter-Thompson type dwarfism. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino-acid signal peptide and a 348 amino-acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant murine GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids.

Cytokines & Growth Factors

50,942 Da

growth differentiation factor 6

growth/differentiation factor 6; GDF-6; growth differentiation factor 16; growth/differentiation factor 16

Growth/differentiation factor 6

Gdf-6; Gdf16; GDF-6??[Similar Products]

GDF6_MOUSE

Function: Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. May signal through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A. Ref.3 Ref.4 Ref.5

Subunit structure: Homodimer; disulfide-linked

By similarity.

Subcellular location: Secreted

By similarity.

Tissue specificity: Expressed in different subsets of developing joints. Ref.3

Disruption phenotype: Mice lacking Gdf6 display photoreceptor degeneration. Animals exhibit abnormal electroretinograms with up to 66% decreases in the bipolar cell-driven b-wave and 54% decreases in the photoreceptor-mediated a-wave amplitudes, as well as 3 to 27% reduced photopic flicker fusion. Ref.5

Sequence similarities: Belongs to the TGF-beta family.

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