Full Product Name
GDF-6 Polyclonal Antibody
Product Synonym Names
GDF6; GDF16; Growth/differentiation factor 6; GDF-6; Growth/differentiation factor 16
Product Gene Name
anti-GDF-6 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from the Internal region of human GDF-6.
Buffer
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-GDF-6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GDF-6 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-GDF-6 antibody
WB: 1:500-1:2000, ELISA: 1:5000-1:20000
Western Blot (WB) of anti-GDF-6 antibody
Western Blot analysis of Rat kidney using GDF-6 Polyclonal Antibody at dilution of 1:500.
NCBI/Uniprot data below describe general gene information for GDF-6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001001557.1
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NCBI GenBank Nucleotide #
NM_001001557.2
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UniProt Secondary Accession #
Q6PI58[Other Products]
UniProt Related Accession #
Q6KF10[Other Products]
Molecular Weight
Calculated MW: 51
Observed MW: 50
NCBI Official Full Name
growth/differentiation factor 6
NCBI Official Synonym Full Names
growth differentiation factor 6
NCBI Official Symbol
GDF6??[Similar Products]
NCBI Official Synonym Symbols
KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; LCA17; MCOP4; SCDO4; BMP-13; MCOPCB6
??[Similar Products]
NCBI Protein Information
growth/differentiation factor 6
UniProt Protein Name
Growth/differentiation factor 6
UniProt Synonym Protein Names
Bone morphogenetic protein 13; BMP-13; Growth/differentiation factor 16
UniProt Gene Name
GDF6??[Similar Products]
UniProt Synonym Gene Names
BMP13; GDF16; GDF-6; BMP-13??[Similar Products]
UniProt Entry Name
GDF6_HUMAN
NCBI Summary for GDF-6
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation. [provided by RefSeq, Jul 2008]
UniProt Comments for GDF-6
GDF6: Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Defects in GDF6 are the cause of Klippel-Feil syndrome type 1 (KFS1). A skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement. Deafness is a well- known feature of KFS and may be of sensorineural, conductive, or mixed type. A chromosomal aberration involving GDF6 has been found in a patient with Klippel-Feil syndrome (KFS). Paracentric inv(8)(q22;2q23.3). Defects in GDF6 are the cause of microphthalmia isolated type 4 (MCOP4). A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Belongs to the TGF-beta family.
Protein type: Cell development/differentiation; Cytokine; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 8q22.1
Cellular Component: extracellular space
Molecular Function: cytokine activity; growth factor activity; protein homodimerization activity; transforming growth factor beta receptor binding
Biological Process: activin receptor signaling pathway; apoptosis; BMP signaling pathway; cell development; growth; positive regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade
Disease: Klippel-feil Syndrome 1, Autosomal Dominant; Leber Congenital Amaurosis 17; Microphthalmia, Isolated 4; Microphthalmia, Isolated, With Coloboma 6
Research Articles on GDF-6
1. BMP13 has a role in enhancing extracellular matrix accumulation and inducing cell migration in certain intervertebral disc cells
Precautions
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Disclaimer
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