Full Product Name
Rabbit Anti-Human GDF-6 Polyclonal Antibody
Product Synonym Names
GDF6; GDF16; Growth/differentiation factor 6; GDF-6; Growth/differentiation factor 16
Product Gene Name
anti-GDF-6 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P43028
Specificity
GDF-6 Polyclonal Antibody detects endogenous levels of GDF-6 protein.
Purity/Purification
>=90% by SDS-PAGE
Affinity purified by Protein A.
Form/Format
Lyophilized or Liquid
Concentration
1 mg/mL (lot specific)
Immunogen
Synthesized peptide derived from the Internal region of human GDF-6.
Storage Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Preparation and Storage
Upon delivery aliquot and store at -20 degree C for one year. Avoid repeated freeze/thaw cycles.
The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20 degree C.
When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-8 degree C.
Other Notes
Small volumes of anti-GDF-6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GDF-6 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-GDF-6 antibody
WB: 1:500-2000
ELISA: 1:10000
NCBI/Uniprot data below describe general gene information for GDF-6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_038554.1
[Other Products]
NCBI GenBank Nucleotide #
NM_013526.1
[Other Products]
UniProt Primary Accession #
P43028
[Other Products]
UniProt Secondary Accession #
Q70UT4[Other Products]
UniProt Related Accession #
P43028[Other Products]
NCBI Official Full Name
growth/differentiation factor 6 preproprotein
NCBI Official Synonym Full Names
growth differentiation factor 6
NCBI Official Symbol
Gdf6??[Similar Products]
NCBI Official Synonym Symbols
BMP13; GDF16; BMP-13
??[Similar Products]
NCBI Protein Information
growth/differentiation factor 6
UniProt Protein Name
Growth/differentiation factor 6
UniProt Synonym Protein Names
Bone morphogenetic protein 13; BMP-13; Growth/differentiation factor 16
UniProt Gene Name
Gdf6??[Similar Products]
UniProt Synonym Gene Names
Bmp13; Gdf-6; Gdf16; GDF-6; BMP-13??[Similar Products]
NCBI Summary for GDF-6
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mice lacking a functional copy of this gene exhibit joint and skeletal defects. [provided by RefSeq, Sep 2016]
UniProt Comments for GDF-6
Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal strucutres (PubMed:26774823). Seems to positively regulates differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:12606286, PubMed:16049014). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (PubMed:23527555).
Research Articles on GDF-6
1. Upregulation of Gdf6 restored the osteogenic capacity of old mesenchymal stem cells in vitro and exerted positive effects in vivo on aging-associated pathologies such as reduced lymphopoiesis, insufficient muscle repair, reduced numbers of neural progenitors in the brain, and chronic inflammation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
