Product Name
COH1 (VPS13B), Blocking Peptide
Full Product Name
COH1 Peptide
Product Synonym Names
CHS1; COH1; CHS1; KIAA0532; Vacuolar protein sorting-associated protein 13B; Cohen syndrome protein 1; vacuolar protein sorting 13 homolog B (yeast)
Product Gene Name
VPS13B blocking peptide
[Similar Products]
COH1 peptide (MBS153087) is used for blocking the activity of COH1 antibody (MBS151550)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q7Z7G8
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
17 amino acid peptide near the amino terminus of human COH1.
Preparation and Storage
Store COH1 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of VPS13B blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for VPS13B blocking peptide
Blocking (BL)
Application Notes for VPS13B blocking peptide
COH1 peptide is used for blocking the activity of COH1 antibody.
NCBI/Uniprot data below describe general gene information for VPS13B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_056058
[Other Products]
NCBI GenBank Nucleotide #
NM_015243.2
[Other Products]
UniProt Primary Accession #
Q7Z7G8
[Other Products]
UniProt Secondary Accession #
Q709C6; Q709C7; Q7Z7G4; Q7Z7G5; Q7Z7G6; Q7Z7G7; Q8NB77; Q9NWV1; Q9Y4E7; C9JD30[Other Products]
UniProt Related Accession #
Q7Z7G8[Other Products]
Molecular Weight
448,536 Da
NCBI Official Full Name
vacuolar protein sorting-associated protein 13B isoform 3
NCBI Official Synonym Full Names
vacuolar protein sorting 13 homolog B (yeast)
NCBI Official Symbol
VPS13B??[Similar Products]
NCBI Official Synonym Symbols
CHS1; COH1
??[Similar Products]
NCBI Protein Information
vacuolar protein sorting-associated protein 13B
UniProt Protein Name
Vacuolar protein sorting-associated protein 13B
UniProt Synonym Protein Names
Cohen syndrome protein 1
Protein Family
Vacuolar protein sorting-associated protein
UniProt Gene Name
VPS13B??[Similar Products]
UniProt Synonym Gene Names
CHS1; COH1; KIAA0532??[Similar Products]
UniProt Entry Name
VP13B_HUMAN
NCBI Summary for VPS13B
This gene encodes a potential transmembrane protein that may function in vesicle-mediated transport and sorting of proteins within the cell. This protein may play a role in the development and the function of the eye, hematological system, and central nervous system. Mutations in this gene have been associated with Cohen syndrome. Multiple splice variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for VPS13B
VPS13B: May be involved in protein sorting in post Golgi membrane traffic. Defects in VPS13B are a cause of Cohen syndrome (COH1). COH1 is a rare autosomal recessive disorder characterized by obesity, hypotonia, intellectual deficit, characteristic craniofacial dysmorphism and abnormalities of the hands and feet. Characteristic facial features include high-arched or wave-shaped eyelids, a short philtrum, thick hair and low hairline. Belongs to the VPS13 family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8q22.2
Biological Process: protein transport
Disease: Cohen Syndrome
Research Articles on VPS13B
1. This observation emphasizes that VPS13B analysis should be performed in cases of congenital neutropenia associated with retinopathy, even in the absence of ID, therefore extending the VPS13B phenotype spectrum.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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