Atrial natriuretic peptide receptor 2; Atrial natriuretic peptide receptor type B; ANP-B; ANPR-B; NPR-B; Guanylate cyclase B; GC-B; NPR2; ANPRB; 4.6.1.2

For Research Use Only. Not for use in diagnostic procedures.

Store at 4 degree C

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Small volumes of NPR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9426648 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Atrial natriuretic peptide receptor 2 (NPR2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NPR2. The ELISA analytical biochemical technique of the MBS9426648 kit is based on NPR2 antibody-NPR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NPR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NPR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

111,208 Da

Atrial natriuretic peptide receptor 2

ANPRB; ANP-B; ANPR-B; NPR-B; GC-B??[Similar Products]

ANPB: natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. 21 mutations linked to acromesomelic dysplasia (skeletal malformation). 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 4.6.1.2; Guanylyl cyclase; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); RGC family; RGC group; Receptor, misc.

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: guanylate cyclase complex, soluble; integral to plasma membrane; plasma membrane

Molecular Function: adenylate cyclase activity; guanylate cyclase activity; hormone binding; natriuretic peptide receptor activity; peptide hormone binding; protein binding

Biological Process: cGMP biosynthetic process; receptor guanylyl cyclase signaling pathway; regulation of blood pressure

Disease: Acromesomelic Dysplasia, Maroteaux Type; Epiphyseal Chondrodysplasia, Miura Type; Short Stature With Nonspecific Skeletal Abnormalities

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