Human Probable phospholipid-transporting ATPase VA (ATP10A) ELISA kit; ATP10C; ATPVA; ATPVC; KIAA0566; ATPase type IV; phospholipid transporting (P-type) ; ATPase; Class V; type 10C; aminophospholipid translocase VA; phospholipid-transporting ATPase VA; ATPase; class V; type 10A

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of ATP10A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9326492 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ATPase, class V, type 10A (ATP10A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ATP10A. The ELISA analytical biochemical technique of the MBS9326492 kit is based on ATP10A antibody-ATP10A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ATP10A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ATP10A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

167,688 Da

ATPase, class V, type 10A

probable phospholipid-transporting ATPase VA; ATPase, Class V, type 10C; aminophospholipid translocase VA; P4-ATPase flippase complex alpha subunit ATP10A; ATPase type IV, phospholipid transporting (P-type)

Probable phospholipid-transporting ATPase VA

ATP10C; ATPVA; ATPVC; KIAA0566??[Similar Products]

AT10A_HUMAN

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'. [provided by RefSeq, Jul 2008]

ATP10A: Defects in ATP10A are a cause of Angelman syndrome (AS); also known as 'happy puppet syndrome'. AS is characterized by features of severe motor and intellectual retardation, microcephaly, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, hyperactivity, hypopigmentation, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, and an unusual facies characterized by macrostomia, a large mandible and open-mouthed expression, a great propensity for protruding the tongue ('tongue thrusting'), and an occipital groove. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.

Protein type: Membrane protein, integral; Hydrolase; Membrane protein, multi-pass; EC 3.6.3.1; Transporter, ion channel; Transporter

Chromosomal Location of Human Ortholog: 15q11.2

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; plasma membrane

Molecular Function: phospholipid-translocating ATPase activity; protein binding; magnesium ion binding; ATP binding

Biological Process: phospholipid translocation; regulation of cell shape; intracellular protein transport; metabolic process; transmembrane transport

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