Product Name
2-hydroxyacylsphingosine 1-beta-galactosyltransferase (Ugt8), Recombinant Protein
Full Product Name
Recombinant Mouse 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (Ugt8)
Product Gene Name
Ugt8 recombinant protein
[Similar Products]
Product Synonym Gene Name
Cgt; Ugt4; Ugt8a[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
21-541aa; full length protein
Sequence
AKIIIVPPIM FESHLYIFKT LASALHERGH HTVLLLSEGR DIAPSNHYSL QRYPGIFNST TSDAFLQSKM RNIFSGRLTA VELVDILDHY TKNCDMMVGN QALIQGLKKE KFDLLLVDPN DMCGFVIAHL LGVKYAVFST GLWYPAEVGA PAPLAYVPEF NSLLTDRMNF LERMKNTGVY LISRIGVSFL VLPKYERIMQ KYNLLPAKSM YDLVHGSSLW MLCTDVALEF PRPTLPNVVY VGGILTKPAS PLPEDLQRWV SGAQEHGFVL VSFGAGVKYL SEDIANKLAG ALGRLPQKVI WRFSGTKPKN LGNNTKLIEW LPQNDLLGHS NIRAFLSHGG LNSIFETMYH GVPVVGIPLF GDHYDTMTRV QAKGMGILLE WNTVTEGELY DALVKVINNP SYRQRAQKLS EIHKDQPGHP VNRTTYWIDY ILRHDGARHL RSAVHQISFC QYFLLDIAFV LLLGAVLLYF ILSYVTKFIY RKIKSLWSKN EHSTVNGHYQ NGIRNGKYKG NGRVKHEKKV R
3D Structure
ModBase 3D Structure for Q64676
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Ugt8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Ugt8 recombinant protein
Transmembrane Protein
Application Notes for Ugt8 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Ugt8. It may not necessarily be applicable to this product.
NCBI Accession #
NP_035804.2
[Other Products]
NCBI GenBank Nucleotide #
NM_011674.4
[Other Products]
UniProt Primary Accession #
Q64676
[Other Products]
UniProt Secondary Accession #
Q61634; Q91W57[Other Products]
UniProt Related Accession #
Q64676[Other Products]
Molecular Weight
61,249 Da
NCBI Official Full Name
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
NCBI Official Synonym Full Names
UDP galactosyltransferase 8A
NCBI Official Symbol
Ugt8a??[Similar Products]
NCBI Official Synonym Symbols
Cgt; Ugt8; mCerGT; AI850488; AW455908
??[Similar Products]
NCBI Protein Information
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
UniProt Protein Name
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
UniProt Synonym Protein Names
Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose-ceramide galactosyltransferase
Protein Family
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
UniProt Gene Name
Ugt8??[Similar Products]
UniProt Synonym Gene Names
Cgt; Ugt4; Ugt8a??[Similar Products]
UniProt Entry Name
CGT_MOUSE
UniProt Comments for Ugt8
UGT8: Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. Belongs to the UDP-glycosyltransferase family.
Protein type: Membrane protein, integral; EC 2.4.1.45; Transferase; Lipid Metabolism - sphingolipid
Cellular Component: integral to membrane; intracellular membrane-bound organelle; membrane
Molecular Function: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity; ceramide glucosyltransferase activity; glucuronosyltransferase activity; transferase activity; transferase activity, transferring glycosyl groups; transferase activity, transferring hexosyl groups; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
Biological Process: cytoskeleton organization and biogenesis; flavonoid biosynthetic process; glycolipid biosynthetic process; lipid metabolic process; metabolic process; myelination; neurite morphogenesis; paranodal junction assembly; sphingolipid metabolic process
Research Articles on Ugt8
1. Our study showed that the additional deletion of Fa2h does not obviously affect the phenotype of Cgt-/- mice. This suggests that HFA-GlcCer and HFA-sphingomyelin do not functionally compensate the loss of HFA-GalCer in Cgt-/- mice.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
