Product Name
NLR family CARD domain-containing protein 4 (NLRC4), Recombinant Protein
Full Product Name
Recombinant Human NLR family CARD domain-containing protein 4 (NLRC4) , partial
Product Gene Name
NLRC4 recombinant protein
[Similar Products]
Product Synonym Gene Name
NLRC4[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
756-889. Partial.
Sequence
TDSLGNLKNL TKLIMDNIKM NEEDAIKLAE GLKNLKKMCL FHLTHLSDIG EGMDYIVKSL SSEPCDLEEI QLVSCCLSAN AVKILAQNLH
NLVKLSIL DLSENYLEKD GNEALHELID RMNVLEQLTA LMLPWG
3D Structure
ModBase 3D Structure for Q9NPP4
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of NLRC4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for NLRC4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001186067.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001199138.1
[Other Products]
UniProt Primary Accession #
Q9NPP4
[Other Products]
UniProt Secondary Accession #
Q96J81; Q96J82; Q96J83; A8K9F8; B2RBQ3; B3KTF0; D6W580[Other Products]
UniProt Related Accession #
Q9NPP4[Other Products]
Molecular Weight
10,646 Da
NCBI Official Full Name
NLR family CARD domain-containing protein 4 isoform a
NCBI Official Synonym Full Names
NLR family CARD domain containing 4
NCBI Official Symbol
NLRC4??[Similar Products]
NCBI Official Synonym Symbols
CLAN; IPAF; AIFEC; CLAN1; CLANA; CLANB; CLANC; CLAND; FCAS4; CARD12; CLR2.1
??[Similar Products]
NCBI Protein Information
NLR family CARD domain-containing protein 4
UniProt Protein Name
NLR family CARD domain-containing protein 4
UniProt Synonym Protein Names
CARD, LRR, and NACHT-containing protein; Clan protein; Caspase recruitment domain-containing protein 12; Ice protease-activating factor; Ipaf
Protein Family
NLR family CARD domain-containing protein
UniProt Gene Name
NLRC4??[Similar Products]
UniProt Synonym Gene Names
CARD12; CLAN; CLAN1; IPAF; Clan protein; Ipaf??[Similar Products]
NCBI Summary for NLRC4
This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
UniProt Comments for NLRC4
Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis.
Research Articles on NLRC4
1. mRNA expression levels of NLRP1 and NLRC4 were not altered in chronic hepatitis B patients, suggesting that these genes are not responsible for the impaired immune responses against HBV observed in these patients.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
