Anti -GRHL2, ID (GRHL2, BOM, TFCP2L3, Grainyhead-like protein 2 homolog, Brother of mammalian grainyhead, Transcription factor CP2-like 3)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 8; NC_000008.10 (102504668..102681954). Location: 8q22.3

Polyclonal

IgG

Rabbit

Human

Affinity Purified
Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-GRHL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).

Antibodies; Abs to Transcription Factors

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

71,105 Da[Similar Products]

grainyhead-like 2 (Drosophila)

grainyhead-like protein 2 homolog; brother of mammalian grainyhead; transcription factor CP2-like 3

Grainyhead-like protein 2 homolog

BOM; TFCP2L3??[Similar Products]

GRHL2_HUMAN

The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).[provided by RefSeq, Mar 2009]

GRHL2: May function as a transcription factor. Defects in GRHL2 are the cause of deafness autosomal dominant type 28 (DFNA28). DFNA28 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA28 is characterized by mild to moderate hearing loss across most frequencies that progressed to severe loss in the higher frequencies by the fifth decade. Age at onset varied, with the earliest case documented at 7 years of age. Belongs to the grh/CP2 family. Grainyhead subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 8q22.3

Cellular Component: membrane; intercellular junction; nucleus

Molecular Function: chromatin DNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: neural tube development; epidermis development; camera-type eye development; transcription, DNA-dependent; in utero embryonic development; multicellular organism growth; negative regulation of keratinocyte differentiation; embryonic cranial skeleton morphogenesis; positive regulation of telomerase activity; regulation of transcription from RNA polymerase II promoter; cell proliferation; neural tube closure; positive regulation of transcription from RNA polymerase II promoter; brain development; embryonic digit morphogenesis; cell adhesion

Disease: Deafness, Autosomal Dominant 28; Ectodermal Dysplasia/short Stature Syndrome

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