Full Product Name
Rabbit Anti-Human ABCG2 Polyclonal Antibody
Product Synonym Names
ABCG2; ABCP; BCRP; BCRP1; MXR; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; CD antigen CD338
Product Gene Name
anti-ABCG2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Specificity
ABCG2 Polyclonal Antibody detects endogenous levels of ABCG2 protein.
Purity/Purification
>=85% by SDS-PAGE
Affinity purified by Protein A.
Form/Format
Lyophilized or Liquid
Concentration
1 mg/mL (lot specific)
Immunogen
Synthesized peptide derived from the Internal region of human ABCG2.
Storage Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Preparation and Storage
Upon delivery aliquot and store at -20 degree C for one year. Avoid repeated freeze/thaw cycles.
The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20 degree C.
When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-8 degree C.
Other Notes
Small volumes of anti-ABCG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCG2 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-ABCG2 antibody
WB: 1:500-2000
IHC: 1:100-300
ELISA: 1:10000
NCBI/Uniprot data below describe general gene information for ABCG2. It may not necessarily be applicable to this product.
NCBI Accession #
AAG52982.1
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UniProt Secondary Accession #
O95374; Q4W5I3; Q53ZQ1; Q569L4; Q5YLG4; Q86V64; Q8IX16; Q96LD6; Q96TA8; A0A1W3; A8K1T5[Other Products]
UniProt Related Accession #
Q9UNQ0[Other Products]
NCBI Official Full Name
ABC transporter ABCG2
NCBI Official Synonym Full Names
ATP binding cassette subfamily G member 2 (Junior blood group)
NCBI Official Symbol
ABCG2??[Similar Products]
NCBI Official Synonym Symbols
MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; MXR-1; CDw338; UAQTL1; EST157481
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NCBI Protein Information
ATP-binding cassette sub-family G member 2
UniProt Protein Name
ATP-binding cassette sub-family G member 2
UniProt Synonym Protein Names
Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter; CD_antigen: CD338
Protein Family
ABC transporter G family
UniProt Gene Name
ABCG2??[Similar Products]
UniProt Synonym Gene Names
ABCP; BCRP; BCRP1; MXR??[Similar Products]
NCBI Summary for ABCG2
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
UniProt Comments for ABCG2
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
Research Articles on ABCG2
1. Results demonstrate a possible role for the ABCG2 rs4148157 allele in the pharmacokinetics of oral topotecan in infants and very young children with brain tumors.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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