Product Name
Atrial Natriuretic Peptide, beta (NPR2), Polyclonal Antibody
Full Product Name
Atrial Natriuretic Peptide, beta (ANP, Atrial Natriuretic Factor, ANF, ATFB6, CDD-ANF, Natriuretic Peptide A, NPPA, Prepronatriodilatin, PND)
Product Synonym Names
Anti -Atrial Natriuretic Peptide, beta (ANP, Atrial Natriuretic Factor, ANF, ATFB6, CDD-ANF, Natriuretic Peptide A, NPPA, Prepronatriodilatin, PND)
Product Gene Name
anti-NPR2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Ser-Leu-Ar g-Arg-Ser- Ser-Cys-Ph e-Gly-Gly- Arg-Met-As p-Arg-Ile- Gly-Ala-Gl n-Ser-Gly- Leu-Gly-Cy s-Asn-Ser- Phe-Arg-Ty r
Chromosome Location
Chromosome: 8; AC_000165.1 (60368097..60379016, complement). Location: chromosome: 8
3D Structure
ModBase 3D Structure for P46197
Species Reactivity
Bovine, Canine, Human, Porcine
Specificity
Recognizes human ANP, beta. Species crossreactivity: bovine, canine and porcine.
Purity/Purification
Purified
Purified
Form/Format
Supplied as a lyophilized powder. Reconstitute with PBS.
Immunogen
Synthetic peptide corresponding to human ANP, beta.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-NPR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-NPR2 antibody
Antibodies; Abs to Cardiac Markers
Applications Tested/Suitable for anti-NPR2 antibody
ELISA (EL/EIA)
Application Notes for anti-NPR2 antibody
Suitable for use in ELISA.
NCBI/Uniprot data below describe general gene information for NPR2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_776551.1
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NCBI GenBank Nucleotide #
NM_174126.2
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UniProt Primary Accession #
P46197
[Other Products]
UniProt Related Accession #
P46197[Other Products]
Molecular Weight
117,146 Da[Similar Products]
NCBI Official Full Name
atrial natriuretic peptide receptor 2
NCBI Official Synonym Full Names
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)<
NCBI Official Symbol
NPR2??[Similar Products]
NCBI Protein Information
atrial natriuretic peptide receptor 2; GC-B; ANP-B; ANPRB; NPR-B; ANPR-B; guanylate cyclase B; atrionatriuretic peptide receptor B; atrial natriuretic peptide receptor B; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor type B
UniProt Protein Name
Atrial natriuretic peptide receptor 2
UniProt Synonym Protein Names
Atrial natriuretic peptide receptor type B; ANP-B; ANPR-B; NPR-B; Guanylate cyclase B
Protein Family
Atrial natriuretic peptide receptor
UniProt Gene Name
NPR2??[Similar Products]
UniProt Synonym Gene Names
ANP-B; ANPR-B; NPR-B; GC-B??[Similar Products]
UniProt Entry Name
ANPRB_BOVIN
UniProt Comments for NPR2
Function: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth
By similarity.
Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate.
Subcellular location: Membrane; Single-pass type I membrane protein.
Post-translational modification: Phosphorylation of the protein kinase-like domain is required for full activation by CNP
By similarity.
Sequence similarities: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.Contains 1 guanylate cyclase domain.Contains 1 protein kinase domain.
Research Articles on NPR2
1. These data support the existence of a novel transducing cascade, involving Galpha(q16)beta gamma coupling M(3)AChR to NPR-GC.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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