Product Name
Atriopeptin I (Npr2), Peptide
Full Product Name
Atriopeptin I (rat, rabbit, mouse)
Product Gene Name
Npr2 peptide
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 5; NC_005104.3 (63653695..63672103). Location: 5q22
3D Structure
ModBase 3D Structure for P16067
Species Reactivity
Mouse, Rabbit, Rat
Purity/Purification
Highly Purified
~95%. Purified by HPLC.
Form/Format
Supplied as a lyophilized powder.
Sequence (linear)
Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Lys-Asn-Ser
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of Npr2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Npr2 peptide
Molecular Biology; MB-Peptides
NCBI/Uniprot data below describe general gene information for Npr2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_446290.1
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NCBI GenBank Nucleotide #
NM_053838.1
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UniProt Primary Accession #
P16067
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UniProt Related Accession #
P16067[Other Products]
Molecular Weight
117,127 Da[Similar Products]
NCBI Official Full Name
atrial natriuretic peptide receptor 2
NCBI Official Synonym Full Names
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
NCBI Official Symbol
Npr2??[Similar Products]
NCBI Official Synonym Symbols
GC-B; NPR-B
??[Similar Products]
NCBI Protein Information
atrial natriuretic peptide receptor 2; ANP-B; ANPRB; ANPR-B; guanylate cyclase B; natriuretic peptide receptor-B; atrial natriuretic peptide receptor B; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor type B
UniProt Protein Name
Atrial natriuretic peptide receptor 2
UniProt Synonym Protein Names
Atrial natriuretic peptide receptor type B; ANP-B; ANPR-B; NPR-B; Guanylate cyclase B
Protein Family
Atrial natriuretic peptide receptor
UniProt Gene Name
Npr2??[Similar Products]
UniProt Synonym Gene Names
ANP-B; ANPR-B; NPR-B; GC-B??[Similar Products]
UniProt Entry Name
ANPRB_RAT
NCBI Summary for Npr2
receptor for atrial natriuretic peptide, brain natriuretic peptide and atriopeptin; has guanylate cyclase activity [RGD, Feb 2006]
UniProt Comments for Npr2
Function: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth
By similarity.
Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate.
Subcellular location: Membrane; Single-pass type I membrane protein.
Post-translational modification: Phosphorylation of the protein kinase-like domain is required for full activation by CNP.
Sequence similarities: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.Contains 1 guanylate cyclase domain.Contains 1 protein kinase domain.
Research Articles on Npr2
1. Six phosphorylation sites were identified in rat GC-B (S513, T516, S518, S523, S526, and T529), and all six sites were also identified in human GC-B.
Precautions
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Disclaimer
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