Product Name
ADRBK1, cDNA Clone
Full Product Name
ADRBK1 cDNA Clone
Product Gene Name
ADRBK1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcggacc tggaggcggt gctggccgac gtgagctacc tgatggccat ggagaagagc aaggccacgc cggccgcgcg cgccagcaag aagatactgc tgcccgagcc cagcatccgc agtgtcatgc agaagtacct ggaggaccgg ggcgaggtga cctttgagaa gatcttttcc cagaagctgg ggtacctgct cttccgagac ttctgcctga accacctgga ggaggccagg cccttggtgg aattctatga ggagatcaag aagtacgaga agctggagac ggaggaggag cgtgtggccc gcagccggga gatcttcgac tcatacatca tgaaggagct gctggcctgc tcgcatccct tctcgaagag tgccactgag catgtccaag gccacctggg gaagaagcag gtgcctccgg atctcttcca gccatacatc gaagagattt gtcaaaacct ccgaggggac gtgttccaga aattcattga gagcgataag ttcacacggt tttgccagtg gaagaatgtg gagctcaaca tccacctgac catgaatgac ttcagcgtgc atcgcatcat tgggcgcggg ggctttggcg aggtctatgg gtgccggaag gctgacacag gcaagatgta cgccatgaag tgcctggaca aaaagcgcat caagatgaag cagggggaga ccctggccct gaacgagcgc atcatgctct cgctcgtcag cactggggac tgcccattca ttgtctgcat gtcatacgcg ttccacacgc cagacaagct cagcttcatc ctggacctca tgaacggtgg ggacctgcac taccacctct cccagcacgg ggtcttctca gaggctgaca tgcgcttcta tgcggccgag atcatcctgg gcctggagca catgcacaac cgcttcgtgg tctaccggga cctgaagcca gccaacatcc ttctggacga gcatggccac gtgcggatct cggacctggg cctggcctgt gacttctcca agaagaagcc ccatgccagc gtgggcaccc acgggtacat ggctccggag gtcctgcaga agggcgtggc ctacgacagc agtgccgact ggttctctct ggggtgcatg ctcttcaagt tgctgcgggg gcacagcccc ttccggcagc acaagaccaa agacaagcat gagatcgacc gcatgacgct gacgatggcc gtggagctgc ccgactcctt ctcccctgaa ctacgctccc tgctggaggg gttgctgcag agggatgtca accggagatt gggctgcctg ggccgagggg ctcaggaggt gaaagagagc ccctttttcc gctccctgga ctggcagatg gtcttcttgc agaagtaccc tcccccgctg atccccccac gaggggaggt gaacgcggcc gacgccttcg acattggctc cttcgatgag gaggacacaa aaggaatcaa gttactggac agtgatcagg agctctaccg caacttcccc ctcaccatct cggagcggtg gcagcaggag gtggcagaga ctgtcttcga caccatcaac gctgagacag accggctgga ggctcgcaag aaagccaaga acaagcagct gggccatgag gaagactacg ccctgggcaa ggactgcatc atgcatggct acatgtccaa gatgggcaac cccttcctga cccagtggca gcggcggtac ttctacctgt tccccaaccg cctcgagtgg cggggcgagg gcgaggcccc gcagagcctg ctgaccatgg aggagatcca gtcggtggag gagacgcaga tcaaggagcg caagtgcctg ctcctcaaga tccgcggtgg gaaacagttc attttgcagt gcgatagcga ccctgagctg gtgcagtgga agaaggagct gcgcgacgcc taccgcgagg cccagcagct ggtgcagcgg gtgcccaaga tgaagaacaa gccgcgctcg cccgtggtgg agctgagcaa ggtgccgctg gtccagcgcg gcagtgccaa cggcctctga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ADRBK1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ADRBK1. It may not necessarily be applicable to this product.
NCBI Accession #
BC037963
[Other Products]
UniProt Secondary Accession #
Q13837; Q6GTT3; B0ZBE1[Other Products]
UniProt Related Accession #
P25098[Other Products]
Molecular Weight
79,574 Da
NCBI Official Full Name
Homo sapiens adrenergic, beta, receptor kinase 1, mRNA
NCBI Official Synonym Full Names
G protein-coupled receptor kinase 2
NCBI Official Symbol
GRK2??[Similar Products]
NCBI Official Synonym Symbols
BARK1; ADRBK1; BETA-ARK1
??[Similar Products]
NCBI Protein Information
beta-adrenergic receptor kinase 1
UniProt Protein Name
Beta-adrenergic receptor kinase 1
UniProt Synonym Protein Names
G-protein coupled receptor kinase 2
UniProt Gene Name
ADRBK1??[Similar Products]
UniProt Synonym Gene Names
BARK; BARK1; GRK2; Beta-ARK-1??[Similar Products]
UniProt Entry Name
ARBK1_HUMAN
NCBI Summary for ADRBK1
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]
UniProt Comments for ADRBK1
GRK2: a ubiquitous protein kinase of the GRK family. Phosphorylates the beta-2-adrenergic receptor and related G-protein-coupled receptors. Appears to mediate agonist-specific desensitization observed at high agonist concentrations. Expression level is consistently elevated in chronic human heart failure. Mouse models of severe heart failure have been used to demonstrate that inhibition of BARK1 with a peptide inhibitor is sufficient to increase mean survival, reduce dialation and improve cardiac function.
Protein type: Protein kinase, AGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.15; AGC group; GRK family; BARK subfamily
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: cytoplasm; cytosol; membrane; plasma membrane
Molecular Function: alpha-2A adrenergic receptor binding; beta-adrenergic receptor kinase activity; Edg-2 lysophosphatidic acid receptor binding; G-protein coupled receptor kinase activity; protein binding; protein kinase activity
Biological Process: acetylcholine receptor signaling, muscarinic pathway; cardiac muscle contraction; desensitization of G-protein coupled receptor protein signaling pathway; entry of virus into host cell; negative regulation of striated muscle contraction; negative regulation of the force of heart contraction by chemical signal; peptidyl-serine phosphorylation; positive regulation of catecholamine secretion; receptor internalization; tachykinin signaling pathway; viral genome replication
Research Articles on ADRBK1
1. the dual-specific GRK2 and ERK cascade inhibitor, RKIP (Raf kinase inhibitor protein), triggered dysfunctional cardiomyocyte energetics and the expression of heart failure-promoting Pparg-regulated genes.
Precautions
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Disclaimer
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