Product Name
Bone Sialoprotein (IBSP), Polyclonal Antibody
Full Product Name
Bone Sialoprotein Antibody
Product Synonym Names
IBSP; Bone Sialoprotein; Bone sialoprotein II; BSP; BSP II; Cell-binding sialoprotein; BNSP; Bone Sialprotein II; Integrin-binding sialoprotein; Bone sialoprotein 2; BSP-II; SP-II
Product Gene Name
anti-IBSP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P21815
Species Reactivity
Human, Mouse
Specificity
Bone Sialoprotein Antibody detects endogenous levels of total Bone Sialoprotein
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (lot specific)
Immunogen
A synthesized peptide derived from human Bone Sialoprotein
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-IBSP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-IBSP antibody
Total protein Ab
Applications Tested/Suitable for anti-IBSP antibody
Western Blot (WB)
Application Notes for anti-IBSP antibody
Western Blot: 1:1000-3000
Western Blot (WB) of anti-IBSP antibody
Western blot analysis Bone Sialoprotein using K562 whole cell lysates
NCBI/Uniprot data below describe general gene information for IBSP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004958.2
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NCBI GenBank Nucleotide #
NM_004967.3
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UniProt Primary Accession #
P21815
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UniProt Related Accession #
P21815[Other Products]
Molecular Weight
35,148 Da[Similar Products]
NCBI Official Full Name
bone sialoprotein 2
NCBI Official Synonym Full Names
integrin binding sialoprotein
NCBI Official Symbol
IBSP??[Similar Products]
NCBI Official Synonym Symbols
BSP; BNSP; SP-II; BSP-II
??[Similar Products]
NCBI Protein Information
bone sialoprotein 2
UniProt Protein Name
Bone sialoprotein 2
UniProt Synonym Protein Names
Bone sialoprotein II; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein
Protein Family
Bone sialoprotein
UniProt Gene Name
IBSP??[Similar Products]
UniProt Synonym Gene Names
BNSP; BSP II??[Similar Products]
UniProt Entry Name
SIAL_HUMAN
NCBI Summary for IBSP
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
UniProt Comments for IBSP
Sialoprotein-2: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q21.1
Cellular Component: extracellular matrix; extracellular region; extracellular space; membrane; vesicle
Biological Process: cell adhesion; extracellular matrix organization and biogenesis; osteoblast differentiation
Research Articles on IBSP
1. Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2-Osterix-BSP Signaling.
Precautions
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Disclaimer
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