Full Product Name
NDP Antibody
Product Gene Name
anti-NDP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q00604
Other Notes
Small volumes of anti-NDP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for NDP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000257.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000266.3
[Other Products]
UniProt Primary Accession #
Q00604
[Other Products]
UniProt Secondary Accession #
Q5JYH5; B2R8K6[Other Products]
UniProt Related Accession #
Q00604[Other Products]
Molecular Weight
15,044 Da
NCBI Official Full Name
norrin
NCBI Official Synonym Full Names
NDP, norrin cystine knot growth factor
NCBI Official Symbol
NDP??[Similar Products]
NCBI Official Synonym Symbols
ND; EVR2; FEVR
??[Similar Products]
NCBI Protein Information
norrin
UniProt Protein Name
Norrin
UniProt Synonym Protein Names
Norrie disease protein; X-linked exudative vitreoretinopathy 2 protein
UniProt Gene Name
NDP??[Similar Products]
UniProt Synonym Gene Names
EVR2??[Similar Products]
NCBI Summary for NDP
This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy. [provided by RefSeq, Feb 2009]
UniProt Comments for NDP
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Research Articles on NDP
1. The screening of candidate genes namely NDP, FZD4 and TSPAN12 led to the identification of six major coding region variants in 36 ROP probands.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
