Full Product Name
NDP Polyclonal Antibody
Product Synonym Names
Norrin; Norrie disease protein; X-linked exudative vitreoretinopathy 2 protein; NDP; EVR2
Product Gene Name
anti-NDP antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q00604
Species Reactivity
Human, Mouse
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 40-120
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-NDP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-NDP antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-NDP antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for NDP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000257.1
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NCBI GenBank Nucleotide #
NM_000266.3
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UniProt Primary Accession #
Q00604
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UniProt Secondary Accession #
Q5JYH5; B2R8K6[Other Products]
UniProt Related Accession #
Q00604[Other Products]
NCBI Official Full Name
norrin
NCBI Official Synonym Full Names
NDP, norrin cystine knot growth factor
NCBI Official Symbol
NDP??[Similar Products]
NCBI Official Synonym Symbols
ND; EVR2; FEVR
??[Similar Products]
NCBI Protein Information
norrin
UniProt Protein Name
Norrin
UniProt Synonym Protein Names
Norrie disease protein; X-linked exudative vitreoretinopathy 2 protein
UniProt Gene Name
NDP??[Similar Products]
UniProt Synonym Gene Names
EVR2??[Similar Products]
NCBI Summary for NDP
This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy. [provided by RefSeq, Feb 2009]
UniProt Comments for NDP
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Research Articles on NDP
1. The screening of candidate genes namely NDP, FZD4 and TSPAN12 led to the identification of six major coding region variants in 36 ROP probands.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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