For Research Use Only. Not for use in diagnostic procedures.

Store at 4 degree C.

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Small volumes of ADRbK1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9136363 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Adrenergic Receptor Beta Kinase 1 (ADRbK1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ADRbK1. The ELISA analytical biochemical technique of the MBS9136363 kit is based on ADRbK1 antibody-ADRbK1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ADRbK1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ADRbK1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Product Overview: The ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of samples in cell culture supernatant, serum, plasma (EDTA, citrate, heparin).
Intended Use: This Human Adrenergic Receptor Beta Kinase 1 (ADRbK1) ELISA kit is intended for laboratory research use only and not for use in diagnostic or therapeutic procedures. The stop solution changes color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration of Human Adrenergic Receptor Beta Kinase 1 (ADRbK1) in the sample, this Human Adrenergic Receptor Beta Kinase 1 (ADRbK1) ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of optical density versus Human Adrenergic Receptor Beta Kinase 1 (ADRbK1) concentration. The concentration of the samples is then determined by comparing the O.D. of the samples to the standard curve.

79,574 Da

G protein-coupled receptor kinase 2

beta-adrenergic receptor kinase 1

Beta-adrenergic receptor kinase 1

ADRBK1; BARK; BARK1; Beta-ARK-1??[Similar Products]

This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017]

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity ().

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