Product Name
Alpha-2C adrenergic receptor (ADRA2C), Recombinant Protein
Full Product Name
Recombinant Human Alpha-2C adrenergic receptor (ADRA2C)
Product Synonym Names
Recombinant Alpha-2C adrenergic receptor (ADRA2C); Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptor subtype C4 Alpha-2C adrenoreceptor; Alpha-2C adrenoceptor; Alpha-2CAR
Product Gene Name
ADRA2C recombinant protein
[Similar Products]
Product Synonym Gene Name
ADRA2C; ADRA2L2, ADRA2RL2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MASPALAAAL AVAAAAGPNA SGAGERGSGG VANASGASWG PPRGQYSAGA VAGLAAVVGF LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV ATLVMPFSLA NELMAYWYFG QVWCGVYLAL DVLFCTSSIV HLCAISLDRY WSVTQAVEYN LKRTPRRVKA TIVAVWLISA VISFPPLVSL YRQPDGAAYP QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR TRTLSEKRAP VGPDGASPTT ENGLGAAAGA GENGHCAPPP ADVEPDESSA AAERRRRRGA LRRGGRRRAG AEGGAGGADG QGAGPGAAES GALTASRSPG PGGRLSRASS RSVEFFLSRR RRARSSVCRR KVAQAREKRF TFVLAVVMGV FVLCWFPFFF SYSLYGICRE ACQVPGPLFK FFFWIGYCNS SLNPVIYTVF NQDFRRSFKH ILFRRRRRGF RQ
Chromosome Location
Chromosome: 4; NC_000004.11 (3768296..3770253). Location: 4p16
3D Structure
ModBase 3D Structure for P18825
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ADRA2C recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ADRA2C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000674.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000683.3
[Other Products]
UniProt Primary Accession #
P18825
[Other Products]
UniProt Secondary Accession #
P35369; Q9HB49[Other Products]
UniProt Related Accession #
P18825[Other Products]
Molecular Weight
49,522 Da[Similar Products]
NCBI Official Full Name
alpha-2C adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor alpha 2C
NCBI Official Symbol
ADRA2C??[Similar Products]
NCBI Official Synonym Symbols
ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR
??[Similar Products]
NCBI Protein Information
alpha-2C adrenergic receptor; alpha-2CAR; alpha2-AR-C4; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2C-adrenergic receptor; adrenergic, alpha-2C-, receptor; alpha-2 adrenergic receptor subtype C4
UniProt Protein Name
Alpha-2C adrenergic receptor
UniProt Synonym Protein Names
Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenoreceptor
Protein Family
Alpha-2C adrenergic receptor
UniProt Gene Name
ADRA2C??[Similar Products]
UniProt Synonym Gene Names
ADRA2L2; ADRA2RL2; Alpha-2C adrenoceptor; Alpha-2CAR??[Similar Products]
UniProt Entry Name
ADA2C_HUMAN
NCBI Summary for ADRA2C
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
UniProt Comments for ADRA2C
Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Polymorphism: The Del322-325 variant has a significant loss of function. It is approximately 10 times more frequent in African-Americans compared with Caucasians (allele frequencies 0.381 versus 0.040).
Sequence similarities: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.
Sequence caution: The sequence AAA35513.1 differs from that shown. Reason: Frameshift at positions 270, 296 and 300. The sequence AAC78723.1 differs from that shown. Reason: Frameshift at positions 270, 296 and 300.
Research Articles on ADRA2C
1. the predicted signal peptide in the N-terminal tail of the alpha(2C)-adrenoceptor does not act as a cleavable signal peptide
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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