Product Name
Alpha-2C adrenergic receptor (Adra2c), Recombinant Protein
Full Product Name
Recombinant Rat Alpha-2C adrenergic receptor (Adra2c)
Product Synonym Names
Recombinant Alpha-2C adrenergic receptor (Adra2c); Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptor subtype C4 Alpha-2C adrenoreceptor; Alpha-2C adrenoceptor; Alpha-2CAR
Product Gene Name
Adra2c recombinant protein
[Similar Products]
Product Synonym Gene Name
Adra2c[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MASPALAAAL AAAAAEGPNG SDAGEWGSGG GANASGTDWG PPPGQYSAGA VAGLAAVVGF LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV ATLVMPFSLA NELMAYWYFG QVWCGVYLAL DVLFCTSSIV HLCAISLDRY WSVTQAVEYN LKRTPRRVKA TIVAVWLISA VISFPPLVSF YRRPDGAAYP QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR TRTLSEKRGP AGPDGASPTT ENGLGKAAGE NGHCAPPRTE VEPDESSAAE RRRRRGALRR GGRRREGAEG DTGSADGPGP GLAAEQGART ASRSPGPGGR LSRASSRSVE FFLSRRRRAR SSVCRRKVAQ AREKRFTFVL AVVMGVFVLC WFPFFFSYSL YGICREACQL PEPLFKFFFW IGYCNSSLNP VIYTVFNQDF RRSFKHILFR RRRRGFRQ
Chromosome Location
Chromosome: 14; NC_005113.3 (81422130..81423833, complement). Location: 14q21
3D Structure
ModBase 3D Structure for P22086
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rattus norvegicus (Rat)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Adra2c recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Adra2c. It may not necessarily be applicable to this product.
NCBI Accession #
NP_612515.1
[Other Products]
NCBI GenBank Nucleotide #
NM_138506.1
[Other Products]
UniProt Primary Accession #
P22086
[Other Products]
UniProt Related Accession #
P22086[Other Products]
Molecular Weight
49,864 Da[Similar Products]
NCBI Official Full Name
alpha-2C adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor alpha 2C
NCBI Official Symbol
Adra2c??[Similar Products]
NCBI Protein Information
alpha-2C adrenergic receptor; alpha-2CAR; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; adrenergic receptor, alpha 2c; adrenergic, alpha-2C-, receptor; Adrenergic alpha2C- receptor class I; Adrenergic, alpha2C-, receptor class I; alpha-2 adrenergic receptor subtype C4
UniProt Protein Name
Alpha-2C adrenergic receptor
UniProt Synonym Protein Names
Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenoreceptor
Protein Family
Alpha-2C adrenergic receptor
UniProt Gene Name
Adra2c??[Similar Products]
UniProt Synonym Gene Names
Alpha-2C adrenoceptor; Alpha-2CAR??[Similar Products]
UniProt Entry Name
ADA2C_RAT
UniProt Comments for Adra2c
ADRA2C: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.
Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR
Cellular Component: axon; integral to plasma membrane; cytoplasm; nerve terminal
Molecular Function: G-protein coupled receptor activity; protein homodimerization activity; protein heterodimerization activity; alpha2-adrenergic receptor activity; epinephrine binding; alpha-2A adrenergic receptor binding
Biological Process: platelet activation; G-protein coupled receptor protein signaling pathway; activation of protein kinase B; positive regulation of vasoconstriction; female pregnancy; regulation of sensory perception of pain; positive regulation of neuron differentiation
Research Articles on Adra2c
1. In aging, the alpha-2C receptor mediated feedback inhibition of epinephrine release from the adrenal medulla is preserved in control rats but compromised in hypertensive rats, resulting in increased epinephrine release.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
