Full Product Name
ARBK1 Antibody
Product Synonym Names
ADRBK1; ARBK1; BARK; BARK1; beta-adrenergic receptor kinase 1; beta-ARK-1; G protein receptor kinase 2; G- protein coupled receptor kinase 2; kinase GRK2
Product Gene Name
anti-ARBK1 antibody
[Similar Products]
Product Synonym Gene Name
ADRBK1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P25098
Species Reactivity
Human, Mouse, Rat
Specificity
ARBK1 Antibody detects endogenous levels of total ARBK1 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human ARBK1.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-ARBK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ARBK1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ARBK1 antibody
WB: 1:500~1:1000
ELISA: 1:20000
Western Blot (WB) of anti-ARBK1 antibody
Western blot analysis of lysates from HUVEC cells, using ARBK1 Antibody. The lane on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for ARBK1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001610.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001619.4
[Other Products]
UniProt Primary Accession #
P25098
[Other Products]
UniProt Secondary Accession #
Q13837; Q6GTT3; B0ZBE1[Other Products]
UniProt Related Accession #
P25098[Other Products]
NCBI Official Full Name
beta-adrenergic receptor kinase 1
NCBI Official Synonym Full Names
G protein-coupled receptor kinase 2
NCBI Official Symbol
GRK2??[Similar Products]
NCBI Official Synonym Symbols
BARK1; ADRBK1; BETA-ARK1
??[Similar Products]
NCBI Protein Information
beta-adrenergic receptor kinase 1
UniProt Protein Name
Beta-adrenergic receptor kinase 1
UniProt Synonym Protein Names
G-protein coupled receptor kinase 2
UniProt Gene Name
GRK2??[Similar Products]
UniProt Synonym Gene Names
Beta-ARK-1??[Similar Products]
NCBI Summary for ARBK1
This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017]
UniProt Comments for ARBK1
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
Research Articles on ARBK1
1. KHSV miR-K3 activates the GRK2/CXCR2/AKT axis inducing KSHV-induced angiogenesis and promoting KSHV latency.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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