Full Product Name
ARBK1 Polyclonal Antibody
Product Synonym Names
Beta-adrenergic receptor kinase 1; Beta-ARK-1; EC 2.7.11.15; G-protein coupled receptor kinase 2; ADRBK1; BARK; BARK1; GRK2
Product Gene Name
anti-ARBK1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P25098
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 1-80
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-ARBK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ARBK1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ARBK1 antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for ARBK1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001610.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001619.4
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UniProt Primary Accession #
P25098
[Other Products]
UniProt Secondary Accession #
Q13837; Q6GTT3; B0ZBE1[Other Products]
UniProt Related Accession #
P25098[Other Products]
NCBI Official Full Name
beta-adrenergic receptor kinase 1
NCBI Official Synonym Full Names
G protein-coupled receptor kinase 2
NCBI Official Symbol
GRK2??[Similar Products]
NCBI Official Synonym Symbols
BARK1; ADRBK1; BETA-ARK1
??[Similar Products]
NCBI Protein Information
beta-adrenergic receptor kinase 1
UniProt Protein Name
Beta-adrenergic receptor kinase 1
UniProt Synonym Protein Names
G-protein coupled receptor kinase 2
UniProt Gene Name
GRK2??[Similar Products]
UniProt Synonym Gene Names
Beta-ARK-1??[Similar Products]
NCBI Summary for ARBK1
This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017]
UniProt Comments for ARBK1
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity ().
Research Articles on ARBK1
1. A novel regulatory role of GRK2 was proposed for the ubiquitination of beta-arrestin in the context of the PKC-mediated heterologous regulation of GPCRs.
Precautions
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Disclaimer
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