Product Name
HSD17B4, cDNA Clone
Full Product Name
HSD17B4 cDNA Clone
Product Gene Name
HSD17B4 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgggctcac cgctgaggtt cgacgggcgg gtggtactgg tcaccggcgc gggggcagga ttgggccgag cctatgccct ggcttttgca gaaagaggag cgttagttgt tgtgaatgat ttgggagggg acttcaaagg agttggtaaa ggctccttag ctgctgataa ggttgttgaa gaaataagaa ggagaggtgg aaaagcagtg gccaactatg attcagtgga agaaggagag aaggttgtga agacagccct ggatgctttt ggaagaatag atgttgtggt caacaatgct ggaattctga gggatcgttc ctttgctagg ataagtgatg aagactggga tataatccac agagttcatt tgcggggttc attccaagtg acacgggcag catgggaaca catgaagaaa cagaagtatg gaaggattat tatgacttca tcagcttcag gaatatatgg caactttggc caggccaatt atagtgctgc aaagttgggt cttctgggcc ttgcaaattc tcttgcaatt gaaggcagga aaagcaacat tcattgtaac accattgctc ctaatgcggg atcacggatg actcagacag ttatgcctga agatcttgtg gaagccctga agccagagta tgtggcacct cttgtccttt ggctttgtca cgagagttgt gaggagaatg gtggcttgtt tgaggttgga gcaggatgga ttggaaaatt acgctgggag cggactcttg gagctattgt aagacaaaag aatcacccaa tgactcctga ggcagtcaag gctaactgga agaagatctg tgactttgag aatgccagca agcctcagag tatccaagaa tcaactggca gtataattga agttctgagt aaaatagatt cagaaggagg agtttcagca aatcatacta gtcgtgcaac gtctacagca acatcaggat ttgctggagc tattggccag aaactccctc cattttctta tgcttatacg gaactggaag ctattatgta tgcccttgga gtgggagcgt caatcaagga tccaaaagat ttgaaattta tttatgaagg aagttctgat ttctcctgtt tgcccacctt cggagttatc ataggtcaga aatctatgat gggtggagga ttagcagaaa ttcctggact ttcaatcaac tttgcaaagg ttcttcatgg agagcagtac ttagagttat ataaaccact tcccagagca ggaaaattaa aatgtgaagc agttgttgct gatgtcctag ataaaggatc cggtgtagtg attattatgg atgtctattc ttattctgag aaggaactta tatgccacaa tcagttctct ctctttcttg ttggctctgg aggctttggt ggaaaacgga catcagacaa agtcaaggta gctgtagcca tacctaatag acctcctgat gctgtactta cagataccac ctctcttaat caggctgctt tgtaccgcct cagtggagac tggaatccct tacacattga tcctaacttt gctagtctag caggttttga caagcccata ttacatggat tatgtacatt tggattttct gccaggcgtg tgttacagca gtttgcagat aatgatgtgt caagattcaa ggcaattaag gctcgttttg caaaaccagt atatccagga caaactctac aaactgagat gtggaaggaa ggaaacagaa ttcattttca aaccaaggtc caagaaactg gagacattgt catttcaaat gcatatgtgg atcttgcacc aacatctggt acttcagcta agacaccctc tgagggcggg aagcttcaga gtacctttgt atttgaggaa ataggacgcc gcctaaagga tattgggcct gaggtggtga agaaagtaaa tgctgtattt gagtggcata taaccaaagg cggaaatatt ggggctaagt ggactattga cctgaaaagt ggttctggaa aagtgtacca aggccctgca aaaggtgctg ctgatacaac aatcatactt tcagatgaag atttcatgga ggtggtcctg ggcaagcttg accctcagaa ggcattcttt agtggcaggc tgaaggccag agggaacatc atgctgagcc agaaacttca gatgattctt aaagactacg ccaagctctg a
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of HSD17B4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for HSD17B4. It may not necessarily be applicable to this product.
NCBI Accession #
BC003098
[Other Products]
UniProt Secondary Accession #
B4DNV1; B4DVS5; E9PB82; F5HE57[Other Products]
UniProt Related Accession #
P51659[Other Products]
Molecular Weight
77,870 Da
NCBI Official Full Name
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 4, mRNA
NCBI Official Synonym Full Names
hydroxysteroid 17-beta dehydrogenase 4
NCBI Official Symbol
HSD17B4??[Similar Products]
NCBI Official Synonym Symbols
DBP; MFE-2; MPF-2; PRLTS1; SDR8C1
??[Similar Products]
NCBI Protein Information
peroxisomal multifunctional enzyme type 2
UniProt Protein Name
Peroxisomal multifunctional enzyme type 2
UniProt Synonym Protein Names
17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4
UniProt Gene Name
HSD17B4??[Similar Products]
UniProt Synonym Gene Names
EDH17B4; SDR8C1; MFE-2; 17-beta-HSD 4; DBP; MPF-2??[Similar Products]
UniProt Entry Name
DHB4_HUMAN
NCBI Summary for HSD17B4
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
UniProt Comments for HSD17B4
HSD17B4: Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids. Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD). DBPD is a disorder of peroxisomal fatty acid beta-oxidation. Defects in HSD17B4 are the cause of Perrault syndrome (PRS). PRS is a sex-influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Some patients also have neurologic manifestations, including mild mental retardation and cerebellar and peripheral nervous system involvement. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: Oxidoreductase; Mitochondrial; EC 4.2.1.119; Cell development/differentiation; Lyase; EC 1.1.1.n12; EC 4.2.1.107; Lipid Metabolism - primary bile acid biosynthesis
Chromosomal Location of Human Ortholog: 5q21
Cellular Component: intracellular membrane-bound organelle; membrane; peroxisomal matrix; peroxisomal membrane; peroxisome
Molecular Function: 3-hydroxyacyl-CoA dehydrogenase activity; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity; long-chain-enoyl-CoA hydratase activity; protein homodimerization activity; receptor binding
Biological Process: androgen metabolic process; bile acid biosynthetic process; estrogen metabolic process; fatty acid beta-oxidation; fatty acid beta-oxidation using acyl-CoA oxidase; osteoblast differentiation
Disease: D-bifunctional Protein Deficiency; Perrault Syndrome 1
Research Articles on HSD17B4
1. Results show that HSD17B4 is highly expressed in hepatocellular carcinoma (HCC) cells and activated NF-kappaB co-localized with the NF-kappaB-responsive element of HSD17B4 suggesting that HSD17B4 plays an important role in aggravated HCC progression.
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Disclaimer
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