Full Product Name
NDP Antibody, Biotin conjugated
Product Synonym Names
Norrin; Norrie disease protein; X-linked exudative vitreoretinopathy 2 protein; NDP; EVR2
Product Gene Name
anti-NDP antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q00604
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Norrin protein (25-133AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-NDP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NDP antibody
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Product Categories/Family for anti-NDP antibody
Neuroscience; Stem cells
Applications Tested/Suitable for anti-NDP antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for NDP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000257.1
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NCBI GenBank Nucleotide #
NM_000266.3
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UniProt Primary Accession #
Q00604
[Other Products]
UniProt Secondary Accession #
Q5JYH5; B2R8K6[Other Products]
UniProt Related Accession #
Q00604[Other Products]
Molecular Weight
15,044 Da
NCBI Official Full Name
norrin
NCBI Official Synonym Full Names
NDP, norrin cystine knot growth factor
NCBI Official Symbol
NDP??[Similar Products]
NCBI Official Synonym Symbols
ND; EVR2; FEVR
??[Similar Products]
NCBI Protein Information
norrin
UniProt Protein Name
Norrin
UniProt Synonym Protein Names
Norrie disease protein; X-linked exudative vitreoretinopathy 2 protein
UniProt Gene Name
NDP??[Similar Products]
UniProt Synonym Gene Names
EVR2??[Similar Products]
NCBI Summary for NDP
This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy. [provided by RefSeq, Feb 2009]
UniProt Comments for NDP
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Research Articles on NDP
1. A mutation of NDP gene is a novel mutation and broadens the genetic spectrum of Norrie disease.">c.314C>A mutation of NDP gene is a novel mutation and broadens the genetic spectrum of Norrie disease.
Precautions
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