Anti -SAR1B, ID (SAR1B, SARA2, SARB, GTP-binding protein SAR1b, GTP-binding protein B)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 2; NC_010444.3 (142463692..142489104, complement). Location: chromosome: 2

Polyclonal

IgG

Rabbit

Human

Affinity Purified
Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-SAR1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene.

Antibodies; Abs to Binding Proteins

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50

22,382 Da[Similar Products]

GTP-binding protein SAR1b; SAR1 gene homolog B; SAR1a gene homolog 2

GTP-binding protein SAR1b

SAR1B_PIG

Function: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex

By similarity.

Subunit structure: Homodimer. Binds PREB. Part of the COPII coat complex. Binds to the cytoplasmic tails of target proteins in the endoplasmic reticulum

By similarity.

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein

By similarity. Golgi apparatus ? Golgi stack membrane; Peripheral membrane protein

By similarity. Note: Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region

By similarity.

Sequence similarities: Belongs to the small GTPase superfamily. SAR1 family.

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