Product Name
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (HMGCS1), Polyclonal Antibody
Full Product Name
Rabbit anti-human 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) polyclonal Antibody
Product Synonym Names
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); HMGCS1; HMGCS; MGC90332
Product Gene Name
anti-HMGCS1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-32422 / sc-32423 / sc-33829
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-HMGCS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-HMGCS1 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
NCBI/Uniprot data below describe general gene information for HMGCS1. It may not necessarily be applicable to this product.
NCBI Accession #
AAH83514.1
[Other Products]
UniProt Secondary Accession #
B2RDL8[Other Products]
UniProt Related Accession #
Q01581[Other Products]
Molecular Weight
57,294 Da[Similar Products]
NCBI Official Full Name
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
NCBI Official Synonym Full Names
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
NCBI Official Symbol
HMGCS1??[Similar Products]
NCBI Official Synonym Symbols
HMGCS
??[Similar Products]
NCBI Protein Information
hydroxymethylglutaryl-CoA synthase, cytoplasmic; 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
UniProt Protein Name
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
UniProt Synonym Protein Names
3-hydroxy-3-methylglutaryl coenzyme A synthase
Protein Family
Hydroxymethylglutaryl-CoA synthase
UniProt Gene Name
HMGCS1??[Similar Products]
UniProt Synonym Gene Names
HMGCS; HMG-CoA synthase??[Similar Products]
UniProt Entry Name
HMCS1_HUMAN
UniProt Comments for HMGCS1
HMGCS1: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Belongs to the HMG-CoA synthase family.
Protein type: Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.3.3.10; Transferase; Lipid Metabolism - synthesis and degradation of ketone bodies; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation
Chromosomal Location of Human Ortholog: 5p14-p13
Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol; nucleus
Molecular Function: protein homodimerization activity; organic acid binding; hydroxymethylglutaryl-CoA synthase activity; isomerase activity; drug binding
Biological Process: response to drug; response to purine; isoprenoid biosynthetic process; male gonad development; cellular lipid metabolic process; liver development; cholesterol biosynthetic process; response to low light intensity; response to vitamin E; response to tellurium ion; response to lipoprotein stimulus; brain development; lipid metabolic process
Research Articles on HMGCS1
1. The authors report high-resolution crystal structures of the human cytosolic (hHMGCS1) and mitochondrial (hHMGCS2) isoforms in binary product complexes.
Precautions
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Disclaimer
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