Product Name
3-ketoacyl-CoA thiolase (THIK), Recombinant Protein
Full Product Name
Recombinant Human 3-ketoacyl-CoA thiolase, peroxisomal
Product Synonym Names
Acetyl-CoA acyltrans ferase; Beta-ketothiolase, Peroxisomal 3-oxoacyl-CoA thiolase
Product Gene Name
THIK recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
Full Length of isoform 2, 27-331aa
3D Structure
ModBase 3D Structure for P09110
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Form/Format
20mM Tris-HCl based buffer, pH8.0
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Other Notes
Small volumes of THIK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for THIK. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001123882.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001130410.1
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UniProt Primary Accession #
P09110
[Other Products]
UniProt Secondary Accession #
Q96CA6; G5E935[Other Products]
UniProt Related Accession #
P09110[Other Products]
NCBI Official Full Name
3-ketoacyl-CoA thiolase, peroxisomal isoform b
NCBI Official Synonym Full Names
acetyl-CoA acyltransferase 1
NCBI Official Symbol
ACAA1??[Similar Products]
NCBI Official Synonym Symbols
ACAA; THIO; PTHIO
??[Similar Products]
NCBI Protein Information
3-ketoacyl-CoA thiolase, peroxisomal
UniProt Protein Name
3-ketoacyl-CoA thiolase, peroxisomal
UniProt Synonym Protein Names
Acetyl-CoA acyltransferase; Beta-ketothiolase; Peroxisomal 3-oxoacyl-CoA thiolase
Protein Family
3-ketoacyl-CoA thiolase
UniProt Gene Name
ACAA1??[Similar Products]
UniProt Synonym Gene Names
ACAA; PTHIO??[Similar Products]
NCBI Summary for THIK
This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Comments for THIK
ACAA1: an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Protein type: Acetyltransferase; Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 2.3.1.16; Lipid Metabolism - fatty acid; Lipid Metabolism - unsaturated fatty acid biosynthesis
Chromosomal Location of Human Ortholog: 3p22.2
Cellular Component: extracellular region; intracellular membrane-bound organelle; membrane; peroxisomal matrix; peroxisome
Molecular Function: acetate CoA-transferase activity; acetyl-CoA C-acyltransferase activity; palmitoyl-CoA oxidase activity; protein binding
Biological Process: bile acid metabolic process; fatty acid beta-oxidation; fatty acid beta-oxidation using acyl-CoA oxidase; neutrophil degranulation; very-long-chain fatty acid metabolic process
Disease: D-bifunctional Protein Deficiency
Research Articles on THIK
1. Findings suggest that protective effects of endotoxin exposure on asthma may vary depending upon the presence or absence of a polymorphism in ACAA1.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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