SAR1B; SARA2; SAR1 gene homolog B (S. cerevisiae); CMRD; GTBPB; 2310075M17Rik; GTP-binding protein Sara; SAR1a gene homolog 2; SAR1B / SARA2

For Research Use Only. Not for use in diagnostic procedures.

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of SAR1B blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

22,410 Da

secretion associated Ras related GTPase 1B

GTP-binding protein SAR1b

GTP-binding protein SAR1b

SARA2; SARB; GTBPB??[Similar Products]

SAR1B_HUMAN

The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

SAR1B: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Defects in SAR1B are the cause of chylomicron retention disease (CMRD); also known as Anderson disease (ANDD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets. Belongs to the small GTPase superfamily. SAR1 family.

Protein type: G protein; G protein, monomeric, SAR1; Motility/polarity/chemotaxis; G protein, monomeric

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: cytosol; endoplasmic reticulum membrane

Molecular Function: GTP binding; GTPase activity; metal ion binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; intracellular protein transport; small GTPase mediated signal transduction

Disease: Chylomicron Retention Disease

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