Product Name
SUMO4, cDNA Clone
Full Product Name
SUMO4 cDNA Clone
Product Gene Name
SUMO4 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggccaacg aaaagcccac agaagaagtc aagactgaga acaacaatca tattaatttg aaggtggcgg gacaggatgg ttctgtggtg cagtttaaga ttaagaggca gacaccactt agtaaactaa tgaaagccta ttgtgaacca cggggattgt cagtgaagca gatcagattc cgatttggtg ggcaaccaat cagtggaaca gacaaacctg cacagttgga aatggaagat gaagatacaa ttgatgtgtt tcaacagcct acgggaggtg tctactga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SUMO4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SUMO4. It may not necessarily be applicable to this product.
NCBI Accession #
BC130305
[Other Products]
UniProt Secondary Accession #
A1L3W5[Other Products]
UniProt Related Accession #
Q6EEV6[Other Products]
Molecular Weight
10,685 Da
NCBI Official Full Name
Homo sapiens SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae), mRNA
NCBI Official Synonym Full Names
small ubiquitin-like modifier 4
NCBI Official Symbol
SUMO4??[Similar Products]
NCBI Official Synonym Symbols
IDDM5; SMT3H4; SUMO-4; dJ281H8.4
??[Similar Products]
NCBI Protein Information
small ubiquitin-related modifier 4
UniProt Protein Name
Small ubiquitin-related modifier 4
UniProt Synonym Protein Names
Small ubiquitin-like protein 4
Protein Family
Small ubiquitin-related modifier
UniProt Gene Name
SUMO4??[Similar Products]
UniProt Synonym Gene Names
SMT3H4; SUMO-4??[Similar Products]
UniProt Entry Name
SUMO4_HUMAN
NCBI Summary for SUMO4
This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]
UniProt Comments for SUMO4
SUMO4: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. Belongs to the ubiquitin family. SUMO subfamily.
Protein type: Ubiquitin-like modifier
Chromosomal Location of Human Ortholog: 6q25
Cellular Component: nucleus
Molecular Function: protein tag
Biological Process: protein sumoylation
Disease: Diabetes Mellitus, Insulin-dependent, 5
Research Articles on SUMO4
1. SUMO4 M55V polymorphism and type-2 diabetes were significantly associated with a possible SUMO4 region to type-2 diabetes susceptibility.
Precautions
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Disclaimer
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