Product Name
MCPH1, cDNA Clone
Full Product Name
MCPH1 cDNA Clone
Product Gene Name
MCPH1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgaatgaac acttatcaag cctaattaaa aaaaaacgta aatgtatgca gcccaaggat tttaatttta aaacaccaga aaatgataag agatttcaga agaaatttga gaaaatggct aaagagctac aaaggcaaaa aacaaatcta gatgatgatg tacctattct cttatttgaa tctaatggtt cattaatata tactcccaca attgaaatta atagtagtca ccacagcgca atggagaaga gattacaaga gatgaaggag aaaagggaaa atctttcccc cacctcttcc caaatgattc agcagtctca tgataatcca agtaactctc tgtgtgaagc acctttgaac atttcacgtg atactttgtg ttcagatgaa tactttgctg gtggcttaca ctcatctttt gatgatcttt gtggaaactc aggatgtgga aatcaggaaa ggaagttgga aggatccatt aatgacatta aaagtgatgt gtgtatttct tcacttgtat tgaaagcaaa taatattcat tcatcaccat ctttcactca cctcgataaa tcaagtcctc agaaatttct gagtaatctt tcaaaggaag aaataaactt gcaaagaaat attgcaggta aagtagtcac ccctcaccaa aagcaggctg caggtatgtc tcaggagacg tttgaagaga agtatcgttt gtctcctacc ttatcttcaa caaaaggcca ccttttgata cattcaagac ccaggagttc ctcagtaaag agaaaaagag tatcacatgg ctcccattca cctccgaagg aaaaatgcaa gagaaagagg agcaccagga gatctatcat gccgaggctg cagctgtgca ggtcggaagg caggctgcag cacgtggcgg gacctgccct ggaggctctt agctgtgggg agtcttcata tgatgactat ttttcacctg ataatcttaa ggaaaggtat tcagagaatc ttcctcctga atctcagctg ccatcaagcc ctgctcagtt gagctgcaga agtctttcta agaaggagag aacaagcata tttgaaatgt ctgatttttc ctgcgttggc aaaaaaacca gaacagttga cattaccaat ttcacagcaa aaaccatctc cagtcctcgg aaaactggaa atggtgaagg ccgtgcaact tcgagttgcg tgacttctgc ccctgaagaa gccctaaggt gttgtagaca ggctgggaaa gaagacgcat gcccagaggg aaatggcttt tcttacacca ttgaggaccc tgctcttcca aaaggacatg atgatgattt aactcctttg gaaggaagcc ttgaagaaat gaaagaagcg gttggtctga aaagcacaca gaacaaaggt accacttcca aaatatcaaa ctcctctgaa ggcgaagccc agagtgaaca tgagccatgt tttatagttg actgtaacat ggagacgtct acagaagaga aggaaaactt acccggagga tacagtggaa gtatgtga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MCPH1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MCPH1. It may not necessarily be applicable to this product.
NCBI Accession #
BC030702
[Other Products]
UniProt Secondary Accession #
Q66GU1; Q9H9C7; B4DWW2; E9PGU5; E9PH63[Other Products]
UniProt Related Accession #
Q8NEM0[Other Products]
Molecular Weight
67,915 Da
NCBI Official Full Name
Homo sapiens microcephalin 1, mRNA
NCBI Official Synonym Full Names
microcephalin 1
NCBI Official Symbol
MCPH1??[Similar Products]
NCBI Official Synonym Symbols
MCT; BRIT1
??[Similar Products]
NCBI Protein Information
microcephalin
UniProt Protein Name
Microcephalin
Protein Family
Microcephalin
UniProt Gene Name
MCPH1??[Similar Products]
UniProt Entry Name
MCPH1_HUMAN
NCBI Summary for MCPH1
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
UniProt Comments for MCPH1
MCPH1: a DNA damage responsive protein and transcriptional repressor of human telomere reverse transcriptase. An early responder to DNA damage. Required for double strand break repair via homologous recombination and nonhomologous end joining. Promotes chromatin relaxation by recruiting and maintaining the chromatin remodeling SWI-SNF complex at sites of DNA double strand breakage. Participates in the ATR/Chk1-mediated DNA checkpoint in humans and transcriptionally regulates BRCA1 and Chk1. Plays a role in neurogenesis and regulation of the size of the cerebral cortex. Mutations of MCPH1 can cause microcephaly in humans and appears to play an evolutionarily conserved role in brain development. Alterations have been identified in breast, ovarian and prostate cancer. Appears to coordinate S-M transitions in fly embryos.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component: nucleoplasm
Molecular Function: identical protein binding; protein binding
Disease: Microcephaly 1, Primary, Autosomal Recessive
Research Articles on MCPH1
1. Results show that in addition to the scaffolding function in complex formation, BRUCE has an E3 ligase function to promote BRIT1 deubiquitination by USP8 leading to accumulation of BRIT1 at DNA double-strand break.
Precautions
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Disclaimer
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