Full Product Name
MCPH1, NT (MCPH1, Microcephalin)
Product Synonym Names
Anti -MCPH1, NT (MCPH1, Microcephalin)
Product Gene Name
anti-MCPH1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 8; NC_000008.10 (6264113..6501140). Location: 8p23.1
3D Structure
ModBase 3D Structure for Q8NEM0
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
MCPH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-133 amino acids from the N-terminal region of human MCPH1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-MCPH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MCPH1 antibody
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described.
Product Categories/Family for anti-MCPH1 antibody
Antibodies; Abs to Disease Markers
Applications Tested/Suitable for anti-MCPH1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-MCPH1 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for MCPH1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001166046.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001172575.1
[Other Products]
UniProt Primary Accession #
Q8NEM0
[Other Products]
UniProt Secondary Accession #
Q66GU1; Q9H9C7; B4DWW2; E9PGU5; E9PH63[Other Products]
UniProt Related Accession #
Q8NEM0[Other Products]
Molecular Weight
92,877 Da[Similar Products]
NCBI Official Full Name
microcephalin isoform 3
NCBI Official Synonym Full Names
microcephalin 1
NCBI Official Symbol
MCPH1??[Similar Products]
NCBI Official Synonym Symbols
MCT; BRIT1
??[Similar Products]
NCBI Protein Information
microcephalin; BRCT-repeat inhibitor of TERT expression 1
UniProt Protein Name
Microcephalin
Protein Family
Microcephalin
UniProt Gene Name
MCPH1??[Similar Products]
UniProt Entry Name
MCPH1_HUMAN
NCBI Summary for MCPH1
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
UniProt Comments for MCPH1
MCPH1: a DNA damage responsive protein and transcriptional repressor of human telomere reverse transcriptase. An early responder to DNA damage. Required for double strand break repair via homologous recombination and nonhomologous end joining. Promotes chromatin relaxation by recruiting and maintaining the chromatin remodeling SWI-SNF complex at sites of DNA double strand breakage. Participates in the ATR/Chk1-mediated DNA checkpoint in humans and transcriptionally regulates BRCA1 and Chk1. Plays a role in neurogenesis and regulation of the size of the cerebral cortex. Mutations of MCPH1 can cause microcephaly in humans and appears to play an evolutionarily conserved role in brain development. Alterations have been identified in breast, ovarian and prostate cancer. Appears to coordinate S-M transitions in fly embryos.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component: nucleoplasm; cytoplasm; microtubule organizing center
Molecular Function: identical protein binding; protein binding
Biological Process: mitotic cell cycle; cerebral cortex development
Disease: Microcephaly 1, Primary, Autosomal Recessive
Research Articles on MCPH1
1. The MCPH1 polymorphisms and protein expression were associated with tumorigenesis in breast cancer
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
