Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1; SR Ca(2+)-ATPase 1; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle

For Research Use Only. Not for use in diagnostic procedures.

For long term storage, please store the entire kit at -20 degree C.

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Small volumes of Atp2a1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS289072 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (Atp2a1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Atp2a1. The ELISA analytical biochemical technique of the MBS289072 kit is based on Atp2a1 antibody-Atp2a1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Atp2a1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Atp2a1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

109,409 Da

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

SERCA1; SR Ca(2+)-ATPase 1??[Similar Products]

AT2A1_RAT

catalyzes ATP hydrolysis and calcium ion transport [RGD, Feb 2006]

ATP2A1: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Associated with sarcolipin (SLN) and phospholamban (PLN). Increased contractile activity leads to a decrease in SERCA1 expression, while decreased contractile activity leads to an increase in SERCA1 expression. Skeletal muscle, fast twitch muscle (type II) fibers. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter, ion channel; EC 3.6.3.8; Hydrolase; Membrane protein, multi-pass; Transporter; Endoplasmic reticulum

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; ER-Golgi intermediate compartment; I band; integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; membrane; mitochondrion; perinuclear region of cytoplasm; sarcoplasmic reticulum; sarcoplasmic reticulum membrane

Molecular Function: ATP binding; calcium ion binding; calcium-transporting ATPase activity; nucleotide-sugar transmembrane transporter activity; protein binding; protein homodimerization activity

Biological Process: apoptotic mitochondrial changes; calcium ion transport; cellular calcium ion homeostasis; elevation of endoplasmic reticulum calcium ion concentration; elevation of mitochondrial calcium ion concentration; maintenance of mitochondrion localization; negative regulation of striated muscle contraction; positive regulation of fast-twitch skeletal muscle contraction; reduction of endoplasmic reticulum calcium ion concentration; regulation of muscle contraction; regulation of striated muscle contraction; response to peptide hormone stimulus

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