Product Name
Kallikrein-11 (KLK11), Polyclonal Antibody
Full Product Name
Kallikrein-11 (Cleaved-Ile54) Antibody
Product Synonym Names
hippostasin; K11; kallikrein-11; kallikrein-related peptidase 11; PRSS20; TLSP; trypsin-like protease
Product Gene Name
anti-KLK11 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UBX7
Specificity
Kallikrein-11 (Cleaved-Ile54) Antibody detects endogenous levels of fragment of activated Kallikrein-11 resulting from cleavage adjacent to Ile54.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Cleaved
Immunogen
The antiserum was produced against synthesized peptide derived from human Kallikrein-11.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-KLK11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-KLK11 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-KLK11 antibody
WB: 1:500~1:1000
ELISA: 1:10000
NCBI/Uniprot data below describe general gene information for KLK11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001129504.1
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NCBI GenBank Nucleotide #
NM_001136032.2
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UniProt Primary Accession #
Q9UBX7
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UniProt Secondary Accession #
O75837; Q0WXX5; Q8IXD7; Q9NS65[Other Products]
UniProt Related Accession #
Q9UBX7[Other Products]
NCBI Official Full Name
kallikrein-11 isoform 1
NCBI Official Synonym Full Names
kallikrein related peptidase 11
NCBI Official Symbol
KLK11??[Similar Products]
NCBI Official Synonym Symbols
TLSP; PRSS20
??[Similar Products]
NCBI Protein Information
kallikrein-11
UniProt Protein Name
Kallikrein-11
UniProt Synonym Protein Names
Hippostasin; Serine protease 20; Trypsin-like protease
Protein Family
Kallikrein
UniProt Gene Name
KLK11??[Similar Products]
UniProt Synonym Gene Names
PRSS20; TLSP; hK11??[Similar Products]
NCBI Summary for KLK11
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
UniProt Comments for KLK11
Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
Research Articles on KLK11
1. Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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