Product Name
Kallikrein-11 (KLK11), Antibody
Full Product Name
Kallikrein-11 (Cleaved-Ile54) Antibody
Product Synonym Names
Kallikrein-11 [Precursor]; EC 3.4.21.-; hK11; Hippostasin; Trypsin-like protease; Serine protease 20; Kallikrein-11 inactive chain 1; Kallikrein-11 inactive chain 2; PRSS20; TLSP; UNQ649/PRO1279
Product Gene Name
anti-KLK11 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UBX7
Specificity
Kallikrein-11 (Cleaved-Ile54) antibody detects endogenous levels of fragment of activated Kallikrein-11 resulting from cleavage adjacent to Ile54.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from human Kallikrein-11.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-KLK11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-KLK11 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-KLK11 antibody
WB: 1:500-1:1000
ELISA: 1:10000
Western Blot (WB) of anti-KLK11 antibody
Western blot analysis of extracts from HeLa cells, treated with etoposide (25uM, 24hours), using Kallikrein-11 (Cleaved-Ile54) antibody.
NCBI/Uniprot data below describe general gene information for KLK11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001129504.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001136032.2
[Other Products]
UniProt Primary Accession #
Q9UBX7
[Other Products]
UniProt Secondary Accession #
O75837; Q0WXX5; Q8IXD7; Q9NS65[Other Products]
UniProt Related Accession #
Q9UBX7[Other Products]
Molecular Weight
30,166 Da
NCBI Official Full Name
kallikrein-11 isoform 1
NCBI Official Synonym Full Names
kallikrein related peptidase 11
NCBI Official Symbol
KLK11??[Similar Products]
NCBI Official Synonym Symbols
TLSP; PRSS20
??[Similar Products]
NCBI Protein Information
kallikrein-11
UniProt Protein Name
Kallikrein-11
UniProt Synonym Protein Names
Hippostasin; Serine protease 20; Trypsin-like protease
Protein Family
Kallikrein
UniProt Gene Name
KLK11??[Similar Products]
UniProt Synonym Gene Names
PRSS20; TLSP; hK11??[Similar Products]
NCBI Summary for KLK11
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
UniProt Comments for KLK11
Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
Product References and Citations for anti-KLK11 antibody
Yoshida S., Biochim. Biophys. Acta 1399:225-228(1998). Mitsui S., Biochem. Biophys. Res. Commun. 272:205-211(2000). Yousef G.M., Genomics 63:88-96(2000).
Research Articles on KLK11
1. Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
