Product Name
SIX5, Blocking Peptide
Product Synonym Names
Homeobox protein SIX5; DM locus-associated homeodomain protein; Sine oculis homeobox homolog 5; SIX5; DMAHP
Product Gene Name
SIX5 blocking peptide
[Similar Products]
Product Synonym Gene Name
DMAHP[Similar Products]
Antibody/Peptide Pairs
SIX5 peptide (MBS9219367) is used for blocking the activity of SIX5 antibody (MBS9213036)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8N196
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cytoplasm. Nucleus
Tissue Location
Expressed in ***** but not in fetal eyes. Found in corneal epithelium and endothelium, lens epithelium, ciliary body epithelia, cellular layers of the retina and the sclera.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of SIX5 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SIX5 blocking peptide
Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'- TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity).
NCBI/Uniprot data below describe general gene information for SIX5. It may not necessarily be applicable to this product.
NCBI Accession #
Q8N196.3
[Other Products]
UniProt Primary Accession #
Q8N196
[Other Products]
UniProt Related Accession #
Q8N196[Other Products]
Molecular Weight
74,562 Da
NCBI Official Full Name
Homeobox protein SIX5
NCBI Official Synonym Full Names
SIX homeobox 5
NCBI Official Symbol
SIX5??[Similar Products]
NCBI Official Synonym Symbols
BOR2; DMAHP
??[Similar Products]
NCBI Protein Information
homeobox protein SIX5
UniProt Protein Name
Homeobox protein SIX5
UniProt Synonym Protein Names
DM locus-associated homeodomain protein; Sine oculis homeobox homolog 5
Protein Family
Homeobox protein
UniProt Gene Name
SIX5??[Similar Products]
UniProt Synonym Gene Names
DMAHP??[Similar Products]
UniProt Entry Name
SIX5_HUMAN
NCBI Summary for SIX5
The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2. [provided by RefSeq, Jul 2009]
UniProt Comments for SIX5
SIX5: Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'- TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter. Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3. Defects in SIX5 are the cause of branchiootorenal syndrome type 2 (BOR2). BOR is an autosomal dominant disorder manifested by various combinations of preauricular pits, branchial fistulae or cysts, lacrimal duct stenosis, hearing loss, structural defects of the outer, middle, or inner ear, and renal dysplasia. Associated defects include asthenic habitus, long narrow facies, constricted palate, deep overbite, and myopia. Hearing loss may be due to mondini type cochlear defect and stapes fixation. Penetrance of BOR syndrome is high, although expressivity can be extremely variable. Belongs to the SIX/Sine oculis homeobox family.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: cytoplasm; Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm
Molecular Function: protein binding
Disease: Branchiootorenal Syndrome 2
Research Articles on SIX5
1. Three causative genes for BOR syndrome have been reported thus far: EYA1, SIX1, and SIX5, but the causative genes for approximately half of all BOR patients remain unknown.[review]
Precautions
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