Product Name
microcephalin 1 (MCPH1), ELISA Kit
Full Product Name
Mouse Microcephalin, MCPH1 ELISA Kit
Product Synonym Names
Mouse Microcephalin (MCPH1) ELISA kit; BRIT1; FLJ12847; MCT; BRCT-repeat inhibitor of TERT expression 1; microcephalin; microcephaly; primary autosomal recessive 1; microcephalin 1
Product Gene Name
MCPH1 elisa kit
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
Request Current Manual
3D Structure
ModBase 3D Structure for Q7TT79
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of MCPH1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for MCPH1 purchase
MBS9320835 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the microcephalin 1 (MCPH1) ELISA Kit target analytes in
biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MCPH1. The ELISA analytical biochemical technique of the MBS9320835 kit is based on MCPH1 antibody-MCPH1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MCPH1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MCPH1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for MCPH1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_775281.2
[Other Products]
NCBI GenBank Nucleotide #
NM_173189.2
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UniProt Primary Accession #
Q7TT79
[Other Products]
UniProt Secondary Accession #
Q8BNI9; Q8C9I7[Other Products]
UniProt Related Accession #
Q7TT79[Other Products]
Molecular Weight
90,373 Da
NCBI Official Full Name
microcephalin
NCBI Official Synonym Full Names
microcephaly, primary autosomal recessive 1
NCBI Official Symbol
Mcph1??[Similar Products]
NCBI Official Synonym Symbols
MCT; BRIT1; 5430437K10Rik; D030046N04Rik
??[Similar Products]
NCBI Protein Information
microcephalin
UniProt Protein Name
Microcephalin
Protein Family
Microcephalin
UniProt Gene Name
Mcph1??[Similar Products]
UniProt Entry Name
MCPH1_MOUSE
UniProt Comments for MCPH1
MCPH1: a DNA damage responsive protein and transcriptional repressor of human telomere reverse transcriptase. An early responder to DNA damage. Required for double strand break repair via homologous recombination and nonhomologous end joining. Promotes chromatin relaxation by recruiting and maintaining the chromatin remodeling SWI-SNF complex at sites of DNA double strand breakage. Participates in the ATR/Chk1-mediated DNA checkpoint in humans and transcriptionally regulates BRCA1 and Chk1. Plays a role in neurogenesis and regulation of the size of the cerebral cortex. Mutations of MCPH1 can cause microcephaly in humans and appears to play an evolutionarily conserved role in brain development. Alterations have been identified in breast, ovarian and prostate cancer. Appears to coordinate S-M transitions in fly embryos.
Protein type: Cell cycle regulation
Cellular Component: cytoskeleton; cell; cytoplasm
Molecular Function: identical protein binding
Biological Process: regulation of centrosome cycle; regulation of kinase activity; establishment of mitotic spindle orientation; regulation of gene expression; regulation of inflammatory response; cerebral cortex development
Research Articles on MCPH1
1. Mcph1-deficient mice reveal a role for MCPH1 in otitis media. Expression of Mcph1 in the epithelial cells of middle ear cavities supported its involvement in the development of otitis media.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
