Bisphosphoglycerate mutase; EC 5.4.2.4; BPGM; 2; 3-bisphosphoglycerate mutase erythrocyte; 2; 3-bisphosphoglycerate synthase; BPG-dependent PGAM; BPGM Antibody; 2, 3-Bisphosphoglycerate Mutase, Mouse Anti Human

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG2a heavy chain and K light chain

PA2E11AT

Mouse

Purified from mouse ascitic fluids by protein-A affinity chromatography

Sterile filtered colorless solution
1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide

For periods up to 1 month store at 4 degree C, for longer periods of time, store at-20 degree C.
Prevent freeze thaw cycles

Small volumes of anti-BPGM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

BPGM is found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. PGM deficiency increases the oxygen affinity of cells. BPGM is a multifunctional enzyme that catalyzes 2, 3-DPG synthesis through its synthetase activity, and 2, 3-DPG degradation using its phosphatase activity. BPGM has phosphoglycerate phosphomutase activity. Mutations in BPGM cause hemolytic anemia. BPGM catalyzes the reaction of EC 5.4.2.1 (mutase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.

MONOCLONAL ANTIBODIES; ANTI-HUMAN ENZYMES; Monoclonal Antibodies; Anti Human Enzyme; BPGM Antibody

ELISA (EIA), Western Blot (WB), Flow cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)

30,005 Da

bisphosphoglycerate mutase

bisphosphoglycerate mutase

Bisphosphoglycerate mutase

DPGM??[Similar Products]

2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]

Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) activity.

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