Product Name
Collagen 4 alpha 1 (COL4A1), Polyclonal Antibody
Full Product Name
Anti-Collagen 4 alpha 1 Antibody
Product Synonym Names
Collagen alpha-1(IV) chain
Product Gene Name
anti-COL4A1 antibody
[Similar Products]
Antibody/Peptide Pairs
Collagen 4 alpha 1 peptide (MBS8248016) is used for blocking the activity of Collagen 4 alpha 1 antibody (MBS8248304)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P02462
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of Collagen 4 alpha 1 protein.
Purity/Purification
The antibody was purified by affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Collagen 4 alpha 1. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-COL4A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-COL4A1 antibody
Rabbit polyclonal antibody to Collagen 4 alpha 1
Applications Tested/Suitable for anti-COL4A1 antibody
Western Blot (WB)
Application Notes for anti-COL4A1 antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-COL4A1 antibody
Western blot analysis of Collagen 4 alpha 1 expression in Hela (A), MCF7 (B), U2OS (C), HEK293T (D), VEC (E) whole cell lysates.
NCBI/Uniprot data below describe general gene information for COL4A1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001290039.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001303110.1
[Other Products]
UniProt Primary Accession #
P02462
[Other Products]
UniProt Secondary Accession #
Q1P9S9; Q5VWF6; Q86X41; Q8NF88; Q9NYC5; A7E2W4; B1AM70[Other Products]
UniProt Related Accession #
P02462[Other Products]
Molecular Weight
127,981 Da
NCBI Official Full Name
collagen alpha-1(IV) chain isoform 2
NCBI Official Synonym Full Names
collagen type IV alpha 1 chain
NCBI Official Symbol
COL4A1??[Similar Products]
NCBI Official Synonym Symbols
BSVD; RATOR
??[Similar Products]
NCBI Protein Information
collagen alpha-1(IV) chain
UniProt Protein Name
Collagen alpha-1(IV) chain
UniProt Gene Name
COL4A1??[Similar Products]
UniProt Entry Name
CO4A1_HUMAN
NCBI Summary for COL4A1
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a
biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Research Articles on COL4A1
1. Hydroxylation and O-linked glycosylation sites in col4a1 from human lens capsule.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
