Product Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (Hsd3b2), Recombinant Protein
Full Product Name
Recombinant Mouse 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (Hsd3b2)
Product Synonym Names
Recombinant 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (Hsd3b2); 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD II Including the followi
Product Gene Name
Hsd3b2 recombinant protein
[Similar Products]
Product Synonym Gene Name
Hsd3b2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
PGWSCLVTGA GGFLGQRIIQ LLVQEEDLEE IRVLDKVFRP ETRKEFFNLE TSIKVTVLEG DILDTQYLRR ACQGISVVIH TAAIIDVTGV IPRQTILDVN LKGTQNLLEA CIQASVPAFI FSSSVDVAGP NSYKEIVLNG HEEECHESTW SDPYPYSKKM AEKAVLAANG SMLKNGGTLQ TCALRPMCIY GERSPLISNI IIMALKHKGI LRSFGKFNTA NPVYVGNVAW AHILAARGLR DPKKSPNIQG EFYYISDDTP HQSFDDISYT LSKEWGFCLD SSWSLPVPLL YWLAFLLETV SFLLSPIYRY IPPFNRHLVT LSGSTFTFSY KKAQRDLGYE PLVSWEEAKQ KTSEWIGTLV EQHRETLDTK SQ
Chromosome Location
Chromosome: 3; NC_000069.6 (98711107..98724543, complement). Location: 3 F2.2; 3 42.85 cM
3D Structure
ModBase 3D Structure for P26149
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mus musculus (Mouse)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Hsd3b2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Hsd3b2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_694873.2
[Other Products]
NCBI GenBank Nucleotide #
NM_153193.3
[Other Products]
UniProt Primary Accession #
P26149
[Other Products]
UniProt Secondary Accession #
Q8R0J6; B1ARN7[Other Products]
UniProt Related Accession #
P26149[Other Products]
Molecular Weight
41,923 Da[Similar Products]
NCBI Official Full Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
NCBI Official Synonym Full Names
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
NCBI Official Symbol
Hsd3b2??[Similar Products]
NCBI Protein Information
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3-beta-HSD II; 3 beta-hydroxysteroid dehydrogenase 2; hydroxysteroid dehydrogenase-2, delta<5>-3-beta; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
UniProt Protein Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
UniProt Synonym Protein Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD II
Protein Family
4-isomerase" title="3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase">3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
UniProt Gene Name
Hsd3b2??[Similar Products]
UniProt Synonym Gene Names
3-beta-HSD II??[Similar Products]
UniProt Entry Name
3BHS2_MOUSE
UniProt Comments for Hsd3b2
HSD3B2: protein localized to the nucleus in proliferating cells that seems to possess a tumor suppressor activity. Directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Suppresses carbonic anhydrase type II protein expression in carcinoid cell lines. Since tumor cells require a high bicarbonate flux for their growth, carbonic anhydrase suppression results in growth inhibition. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two differentially spliced isoforms have been identified.
Protein type: EC 1.1.1.145; Mitochondrial; Endoplasmic reticulum; Membrane protein, integral; Oxidoreductase; EC 5.3.3.1; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Isomerase
Cellular Component: membrane; mitochondrion; endoplasmic reticulum; mitochondrial inner membrane; integral to membrane; mitochondrial intermembrane space
Molecular Function: steroid delta-isomerase activity; 3-beta-hydroxy-delta5-steroid dehydrogenase activity; oxidoreductase activity; isomerase activity; catalytic activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process: metabolic process; steroid biosynthetic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
