Product Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (Hsd3b2), Recombinant Protein
Full Product Name
Recombinant Mouse 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (Hsd3b2)
Product Gene Name
Hsd3b2 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-373aa; Full length protein
Sequence
PGWSCLVTGA GGFLGQRIIQ LLVQEEDLEE IRVLDKVFRP ETRKEFFNLE TSIKVTVLEG DILDTQYLRR ACQGISVVIH TAAIIDVTGV IPRQTILDVN LKGTQNLLEA CIQASVPAFI FSSSVDVAGP NSYKEIVLNG HEEECHESTW SDPYPYSKKM AEKAVLAANG SMLKNGGTLQ TCALRPMCIY GERSPLISNI IIMALKHKGI LRSFGKFNTA NPVYVGNVAW AHILAARGLR DPKKSPNIQG EFYYISDDTP HQSFDDISYT LSKEWGFCLD SSWSLPVPLL YWLAFLLETV SFLLSPIYRY IPPFNRHLVT LSGSTFTFSY KKAQRDLGYE PLVSWEEAKQ KTSEWIGTLV EQHRETLDTK SQ
3D Structure
ModBase 3D Structure for P26149
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Hsd3b2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Hsd3b2 recombinant protein
Transmembrane Protein
Application Notes for Hsd3b2 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Hsd3b2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_694873.2
[Other Products]
NCBI GenBank Nucleotide #
NM_153193.3
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UniProt Primary Accession #
P26149
[Other Products]
UniProt Secondary Accession #
Q8R0J6; B1ARN7[Other Products]
UniProt Related Accession #
P26149[Other Products]
Molecular Weight
41,923 Da
NCBI Official Full Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
NCBI Official Synonym Full Names
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
NCBI Official Symbol
Hsd3b2??[Similar Products]
NCBI Protein Information
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
UniProt Protein Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
UniProt Synonym Protein Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD II
Protein Family
4-isomerase" title="3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase">3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
UniProt Gene Name
Hsd3b2??[Similar Products]
UniProt Synonym Gene Names
3-beta-HSD II??[Similar Products]
UniProt Entry Name
3BHS2_MOUSE
UniProt Comments for Hsd3b2
HSD3B2: protein localized to the nucleus in proliferating cells that seems to possess a tumor suppressor activity. Directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Suppresses carbonic anhydrase type II protein expression in carcinoid cell lines. Since tumor cells require a high bicarbonate flux for their growth, carbonic anhydrase suppression results in growth inhibition. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two differentially spliced isoforms have been identified.
Protein type: Membrane protein, integral; Lipid Metabolism - C21-steroid hormone; Oxidoreductase; Isomerase; Mitochondrial; Lipid Metabolism - androgen and estrogen; Endoplasmic reticulum; EC 1.1.1.145; EC 5.3.3.1
Cellular Component: endoplasmic reticulum; integral to membrane; membrane; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion
Molecular Function: 3-beta-hydroxy-delta5-steroid dehydrogenase activity; catalytic activity; isomerase activity; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; steroid delta-isomerase activity
Biological Process: metabolic process; steroid biosynthetic process
Research Articles on Hsd3b2
1. molecular chaperone-assisted folding of 3-beta hydroxysteroid dehydrogenase-2 is a physiological requirement
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
