For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Affinity Purified

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-B3GLCT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This is a rabbit polyclonal antibody against B3GALTL. It was validated on Western Blot using a cell lysate as a positive control.

Target Description: The protein encoded by this gene is a beta-1,3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. The encoded protein is a type II membrane protein. Defects in this gene are a cause of Peters-plus syndrome (PPS).

Polyclonal; Signal Proteins; Membrane Protein; Drugs and Drug Metabolism;

Western Blot (WB)

WB Suggested Anti-B3GALTL Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: SH-SYSY cell lysate

56kDa

beta 3-glucosyltransferase

beta-1,3-glucosyltransferase

Beta-1,3-glucosyltransferase

B3GTL; Beta3Glc-T??[Similar Products]

B3GLT_HUMAN

The protein encoded by this gene is a beta-1,3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. The encoded protein is a type II membrane protein. Defects in this gene are a cause of Peters-plus syndrome (PPS).[provided by RefSeq, Mar 2009]

B3GALTL: O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. Defects in B3GALTL are the cause of Peters-plus syndrome (PpS). PpS is an autosomal recessive disorder characterized by anterior eye-chamber abnormalities, disproportionate short stature, developmental delay, characteristic craniofacial features, cleft lip and/or palate. Belongs to the glycosyltransferase 31 family.

Protein type: Transferase; EC 2.4.1.-; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: transferase activity, transferring glycosyl groups

Biological Process: fucose metabolic process; protein amino acid O-linked glycosylation; cellular protein metabolic process; post-translational protein modification

Disease: Peters-plus Syndrome

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