Full Product Name
Blmh Antibody - C-terminal region
Product Gene Name
anti-BLMH antibody
[Similar Products]
Product Synonym Gene Name
AI035728; Bh; Bmh[Similar Products]
Antibody/Peptide Pairs
Blmh peptide (MBS3237509) is used for blocking the activity of Blmh antibody (MBS3212562)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: GPITPLQFYK EHVKPLFNME DKICFVNDPR PQHKYNKLYT VDYLSNMVGG
3D Structure
ModBase 3D Structure for Q8R016
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 100%; Dog: 86%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 79%
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Blmh
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-BLMH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BLMH antibody
This is a rabbit polyclonal antibody against Blmh. It was validated on Western Blot
Target Description: The encoded protein is a cytoplasmic cysteine peptidase involved in inactivation of bleomycin, a glycopeptide which is a component of combination chemotherapy regimens for cancer. This encoded enzyme is highly conserved, and it contains the signature active site residues of cysteine protease papain superfamily enzymes. It is postulated that this enzyme has protective effects against bleomycin-induced pulmonary fibrosis and bleomycin tumor resistance.
Product Categories/Family for anti-BLMH antibody
Polyclonal;
Applications Tested/Suitable for anti-BLMH antibody
Western Blot (WB)
Western Blot (WB) of anti-BLMH antibody
Host: Rabbit
Target Name: Blmh
Sample Type: Mouse Stomach lysates
Antibody Dilution: 1.0ug/ml
NCBI/Uniprot data below describe general gene information for BLMH. It may not necessarily be applicable to this product.
NCBI Accession #
NP_848760
[Other Products]
NCBI GenBank Nucleotide #
NM_178645
[Other Products]
UniProt Primary Accession #
Q8R016
[Other Products]
UniProt Related Accession #
Q8R016[Other Products]
NCBI Official Full Name
bleomycin hydrolase
NCBI Official Synonym Full Names
bleomycin hydrolase
NCBI Official Symbol
Blmh??[Similar Products]
NCBI Official Synonym Symbols
Bh; Bmh; AI035728
??[Similar Products]
NCBI Protein Information
bleomycin hydrolase
UniProt Protein Name
Bleomycin hydrolase
Protein Family
Bleomycin hydrolase
UniProt Gene Name
Blmh??[Similar Products]
UniProt Synonym Gene Names
BH; BLM hydrolase; BMH??[Similar Products]
NCBI Summary for BLMH
The encoded protein is a cytoplasmic cysteine peptidase involved in inactivation of bleomycin, a glycopeptide which is a component of combination chemotherapy regimens for cancer. This encoded enzyme is highly conserved, and it contains the signature active site residues of cysteine protease papain superfamily enzymes. It is postulated that this enzyme has protective effects against bleomycin-induced pulmonary fibrosis and bleomycin tumor resistance. [provided by RefSeq, Jan 2010]
UniProt Comments for BLMH
BLMH: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. Belongs to the peptidase C1 family.
Protein type: EC 3.4.22.40; Protease
Chromosomal Location of Human Ortholog: 11|11 B5
Cellular Component: cytoplasm; nucleus
Molecular Function: aminopeptidase activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; hydrolase activity; identical protein binding; peptidase activity
Biological Process: homocysteine catabolic process; proteolysis; response to drug; response to toxin
Research Articles on BLMH
1. Blmh interacts with diverse cellular processes--lipoprotein, amino acid and protein, carbohydrate, and energy metabolisms, detoxification, antioxidant defenses--that are essential for normal kidney homeostasis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
