Full Product Name
ADCK4 Antibody
Product Synonym Names
EC 2.7.11.-; ADCK4; Uncharacterized aarF domain-containing protein kinase 4
Product Gene Name
anti-ADCK4 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96D53
Specificity
The antibody detects endogenous levels of total ADCK4 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Description
Synthesized peptide derived from internal of human ADCK4.
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ADCK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ADCK4 antibody
May play a role in CoQ10 (COQ10A and/or COQ10B) biosynthesis, which is required for podocyte migration.The MGC Project Team, Genome Res. 14:2121-2127(2004).Ota T., Nat. Genet. 36:40-45(2004).
Product Categories/Family for anti-ADCK4 antibody
Total protein Ab
Applications Tested/Suitable for anti-ADCK4 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-ADCK4 antibody
Western blotting: 1:500~1:3000
Immunofluorescence: 1:100~1:500
Western Blot (WB) of anti-ADCK4 antibody
Western blot analysis of extracts from HepG2 cells, using ADCK4 antibody.
Immunofluorescence (IF) of anti-ADCK4 antibody
Immunofluorescence analysis of A549 cells, using ADCK4 antibody.
NCBI/Uniprot data below describe general gene information for ADCK4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001136027.1
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NCBI GenBank Nucleotide #
NM_001142555.2
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UniProt Primary Accession #
Q96D53
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UniProt Secondary Accession #
Q8TAJ1; Q9HA52[Other Products]
UniProt Related Accession #
Q96D53[Other Products]
Molecular Weight
55,853 Da
NCBI Official Full Name
aarF domain-containing protein kinase 4 isoform b
NCBI Official Synonym Full Names
aarF domain containing kinase 4
NCBI Official Symbol
ADCK4??[Similar Products]
NCBI Official Synonym Symbols
NPHS9
??[Similar Products]
NCBI Protein Information
aarF domain-containing protein kinase 4
UniProt Protein Name
AarF domain-containing protein kinase 4
UniProt Gene Name
ADCK4??[Similar Products]
UniProt Entry Name
ADCK4_HUMAN
NCBI Summary for ADCK4
This gene encodes a protein with two copies of a domain found in protein kinases. The encoded protein has a complete protein kinase catalytic domain, and a truncated domain that contains only the active and s of the protein kinase domain, however, it is not known whether the protein has any kinase activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Comments for ADCK4
ADCK4: The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr). Belongs to the protein kinase superfamily. ADCK protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein kinase, atypical; EC 2.7.-.-; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.-; ATYPICAL group; ABC1 family; ABC1-A subfamily
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: mitochondrial membrane; integral to membrane; plasma membrane; cytosol
Molecular Function: protein serine/threonine kinase activity
Biological Process: protein amino acid phosphorylation
Disease: Nephrotic Syndrome, Type 9
Research Articles on ADCK4
1. Mutations in ADCK4 resulted in reduced CoQ10 levels and reduced mitochondrial respiratory enzyme activity in cells isolated from individuals with steroid-resistant nephrotic syndrome & transformed lymphoblasts.
Precautions
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Disclaimer
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