Product Name
AKT-interacting protein (Aktip), Recombinant Protein
Full Product Name
Recombinant Rat AKT-interacting protein (Aktip)
Product Gene Name
Aktip recombinant protein
[Similar Products]
Product Synonym Gene Name
Aktip[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-292aa, full length protein
Sequence
MNPLWSMSSG SVRKRAEGEE KTLAGDVKTS PPRSAPKKQL PSIPKNALPI SKPTSPAPAA QSTNGTHASY GPFYLEYSLL AEFTMVVKQK LPGVYVQPSY RSALVWFGVI FIRHGLYQDG VFKFTVYIPD NYPDGDCPRL LFDIPVFHPL VDPTSGELDV KRAFAKWRRN HNHIWQVLMY ARRVFYKIDT TSPLNPEAAV LYEKDIQLFK SKVVDSVKVC TARLFDQPKI EDPYAISFSP WNPSVHDEAR EKMLTQKKPD EQHNKSVHVA GLSWVKPGSV QPFSKEEKTV AT
3D Structure
ModBase 3D Structure for Q5FVH4
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Aktip recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Aktip recombinant protein
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. This protein is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine
threonine kinase protein kinase B (PKB)
Akt and modulates PKB activity by enhancing the phosphorylation of PKB s regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
NCBI/Uniprot data below describe general gene information for Aktip. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001011926.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001011926.1
[Other Products]
UniProt Primary Accession #
Q5FVH4
[Other Products]
UniProt Related Accession #
Q5FVH4[Other Products]
Molecular Weight
32,992 Da
NCBI Official Full Name
AKT-interacting protein
NCBI Official Synonym Full Names
AKT interacting protein
NCBI Official Symbol
Aktip??[Similar Products]
NCBI Official Synonym Symbols
Fts
??[Similar Products]
NCBI Protein Information
AKT-interacting protein
UniProt Protein Name
AKT-interacting protein
UniProt Synonym Protein Names
Fused toes protein homolog
Protein Family
AKT-interacting protein
UniProt Gene Name
Aktip??[Similar Products]
UniProt Synonym Gene Names
Fts??[Similar Products]
UniProt Comments for Aktip
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
