Product Name
Alpha 1 Antichymotrypsin (SERPINA3), Native Protein
Popular Item
Full Product Name
Alpha 1-Antichymotrypsin
Product Synonym Names
Alpha-1-Antichymotrypsin; Human Alpha-1-Antichymotrypsin
Product Gene Name
SERPINA3 native protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 14; NC_000014.8 (95078714..95090390). Location: 14q32.1
3D Structure
ModBase 3D Structure for P01011
Specificity
Alpha 1 Antichymotrypsin
Purity/Purification
95% pure (SDS-PAGE)
Form/Format
Purified, Lyophilized, Reconstitute in 331 ul deionized water
Concentration
3.02 mg/ml (prior to lyophilization) (lot specific)
Inactivation
Not applicable.
Buffer
Lyophilized from 20mM Tris, pH 7.4 containing 150mM Sodium chloride
Warnings
All human source materials have tested negative for HIV1, HIV2, and non-reactive for HBC and HCV antibodies and HBsAg by FDA. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious
Preparation and Storage
Lyophilized: Store desiccated (up to 12 months) at 2 to 8 degree C.
Reconstituted: Short-term (up to 14 days) store at 2 to 8 degree C. Long term, aliquot and store at -20 degree C to -70 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SERPINA3 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for SERPINA3 native protein
Purified Proteins and Bioactive Peptides
Application Notes for SERPINA3 native protein
Specific methodologies have not been tested using this product.
NCBI/Uniprot data below describe general gene information for SERPINA3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001076.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001085.4
[Other Products]
UniProt Primary Accession #
P01011
[Other Products]
UniProt Secondary Accession #
Q13703; Q2TU87; Q2TU88; Q59GP9; Q6LBY8; Q6LDT7; Q6NSC9; Q8N177; Q96DW8; Q9UC47; B3KVQ7[Other Products]
UniProt Related Accession #
P01011[Other Products]
Molecular Weight
47,651 Da[Similar Products]
NCBI Official Full Name
alpha-1-antichymotrypsin
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
NCBI Official Symbol
SERPINA3??[Similar Products]
NCBI Official Synonym Symbols
ACT; AACT; GIG24; GIG25; MGC88254
??[Similar Products]
NCBI Protein Information
alpha-1-antichymotrypsin; serpin A3; OTTHUMP00000028439; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3
UniProt Protein Name
Alpha-1-antichymotrypsin
UniProt Synonym Protein Names
Cell growth-inhibiting gene 24/25 protein; Serpin A3
Protein Family
Alpha-1-antichymotrypsin
UniProt Gene Name
SERPINA3??[Similar Products]
UniProt Synonym Gene Names
AACT??[Similar Products]
UniProt Entry Name
AACT_HUMAN
NCBI Summary for SERPINA3
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq]
UniProt Comments for SERPINA3
Function: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Ref.14
Subunit structure: Interacts with DNAJC1. Ref.18
Subcellular location: Secreted.
Tissue specificity: Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains. Ref.7 Ref.8
Domain: The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
Miscellaneous: Alpha-1-antichymotrypsin can bind DNA.
Sequence similarities: Belongs to the serpin family.
Caution: It is uncertain whether Met-1 or Met-4 is the initiator.
Sequence caution: The sequence AAA51543.1 differs from that shown. Reason: Frameshift at positions 101, 106, 111, 117, 123, 129 and 421. The sequence AAT08029.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence AAT08029.1 differs from that shown. Reason: Frameshift at position 4. The sequence BAD92297.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA48671.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on SERPINA3
1. The Alpha 1 antichymotrypsin is an independent histological prognostic marker for patients with Melanoma, especially those with Stage III melanoma.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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