Monoclonal Antibody to Alpha-1-Antichymotrypsin

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 14; NC_000014.8 (95078714..95090390). Location: 14q32.1

Monoclonal

IgG1, kappa

802

Mouse

Alpha 1 Antichymotrypsin
Specifically recognizes alpha-1-antichymotrypsin. Does not cross-react with alpha-1-antitrypsin.

Protein G chromatography

Purified, Liquid

1mg/ml (OD280nm) (lot specific)

Upon receipt, aliquot and store at-20 degree C to -70 degree C. Avoid multiple freeze/thaw cycles.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-SERPINA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Monoclonal Antibodies to Proteins and Bioactive Peptides

May be used in immunoassays to detect and quantitate alpha-1-antichymotrypsin. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not neces

47,651 Da[Similar Products]

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

alpha-1-antichymotrypsin; serpin A3; OTTHUMP00000028439; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3

Alpha-1-antichymotrypsin

AACT??[Similar Products]

AACT_HUMAN

The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq]

Function: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Ref.14

Subunit structure: Interacts with DNAJC1. Ref.18

Subcellular location: Secreted.

Tissue specificity: Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains. Ref.7 Ref.8

Domain: The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.

Miscellaneous: Alpha-1-antichymotrypsin can bind DNA.

Sequence similarities: Belongs to the serpin family.

Caution: It is uncertain whether Met-1 or Met-4 is the initiator.

Sequence caution: The sequence AAA51543.1 differs from that shown. Reason: Frameshift at positions 101, 106, 111, 117, 123, 129 and 421. The sequence AAT08029.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence AAT08029.1 differs from that shown. Reason: Frameshift at position 4. The sequence BAD92297.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA48671.1 differs from that shown. Reason: Erroneous initiation.

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