Product Name
Alpha-1-antichymotrypsin (SERPINA3), Monoclonal Antibody
Full Product Name
Alpha-1-Antichymotrypsin Monoclonal Antibody
Product Synonym Names
Anti-Alpha-1-antichymotrypsin; Alpha-1- Anti-Chymotrypsin
Product Gene Name
anti-SERPINA3 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 14; NC_000014.8 (95078714..95090390). Location: 14q32.1
3D Structure
ModBase 3D Structure for P01011
Specificity
Anti-Alpha-1-antichymotrypsin [Human serum alpha-1-antichymo-trypsin (4 clones). LP]
These antibodies specifically recognize alpha-1-antichymotrypsin.They do not cross-react with alpha-1-antitrypsin.
Form/Format
1 ml ascites or 1 mg Protein G-purified antibody in PBS, pH 7.4
Antigen
Purified human serum alpha-1-antichymotrypsin.
Activity
Ig mg/ml* :22.0
ELISA Titer**:1:409,600
(Note: * Determined by radial immunodiffusion for several lots of ascites.
**ELISA is an indirect assay against alpha-1-antichymotrypsin on the solid phase. Titers represent endpoint dilutions that achieve absorbance values >= 0.1)
Preservatives
None. Available on request
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of anti-SERPINA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-SERPINA3 antibody
Enzyme and Enzyme Inhibitor Antibodies
Applications Tested/Suitable for anti-SERPINA3 antibody
Immunoassay
Application Notes for anti-SERPINA3 antibody
These antibodies may be used in immunoassays to detect and quantitate alpha-1-antichymotrypsin. Other applications are under investigation.
NCBI/Uniprot data below describe general gene information for SERPINA3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001076.2
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NCBI GenBank Nucleotide #
NM_001085.4
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UniProt Primary Accession #
P01011
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UniProt Secondary Accession #
Q13703; Q2TU87; Q2TU88; Q59GP9; Q6LBY8; Q6LDT7; Q6NSC9; Q8N177; Q96DW8; Q9UC47; B3KVQ7[Other Products]
UniProt Related Accession #
P01011[Other Products]
Molecular Weight
47,651 Da[Similar Products]
NCBI Official Full Name
alpha-1-antichymotrypsin
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
NCBI Official Symbol
SERPINA3??[Similar Products]
NCBI Official Synonym Symbols
ACT; AACT; GIG24; GIG25; MGC88254
??[Similar Products]
NCBI Protein Information
alpha-1-antichymotrypsin; serpin A3; OTTHUMP00000028439; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3
UniProt Protein Name
Alpha-1-antichymotrypsin
UniProt Synonym Protein Names
Cell growth-inhibiting gene 24/25 protein; Serpin A3
Protein Family
Alpha-1-antichymotrypsin
UniProt Gene Name
SERPINA3??[Similar Products]
UniProt Synonym Gene Names
AACT??[Similar Products]
UniProt Entry Name
AACT_HUMAN
NCBI Summary for SERPINA3
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq]
UniProt Comments for SERPINA3
SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 14q32.1
Cellular Component: extracellular space; extracellular region; intracellular; nucleus
Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; DNA binding
Biological Process: regulation of lipid metabolic process; maintenance of gastrointestinal epithelium; acute-phase response; inflammatory response
Research Articles on SERPINA3
1. The Alpha 1 antichymotrypsin is an independent histological prognostic marker for patients with Melanoma, especially those with Stage III melanoma.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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